HPMC yog hu ua hydroxypropyl methylcellulose.
HPMC cov khoom xaiv cov paj rwb ntshiab heev cellulose ua raw khoom thiab yog tsim los ntawm tshwj xeeb etherification nyob rau hauv alkaline tej yam kev mob.Tag nrho cov txheej txheem tau ua tiav raws li GMP cov xwm txheej thiab kev saib xyuas tsis siv neeg, tsis muaj cov khoom xyaw nquag xws li tsiaj cov kabmob thiab roj.
HPMC cov khoom:
HPMC cov khoom yog non-ionic cellulose ether, cov tsos yog dawb hmoov, tsw tsw qab, soluble nyob rau hauv dej thiab feem ntau polar organic solvents (xws li dichloroethane) thiab tsim nyog feem ntawm ethanol / dej, propyl cawv / dej, thiab lwm yam. Aqueous tov muaj nto. kev ua haujlwm, siab pob tshab thiab kev ua haujlwm ruaj khov.HPMC muaj cov khoom ntawm thermal gel, cov khoom siv dej yog rhuab los ua gel nag lossis daus, thiab tom qab ntawd yaj tom qab txias, qhov sib txawv ntawm cov khoom gel kub yog txawv.Solubility hloov nrog lub viscosity, qhov qis viscosity, ntau dua solubility, txawv specifications ntawm HPMC muaj ib tug tej yam txawv nyob rau hauv nws cov khoom, HPMC nyob rau hauv dej tsis cuam tshuam los ntawm PH nqi.Particle loj: 100 mesh pass tus nqi yog ntau tshaj 100%.Qhov ntom ntom: 0.25-0.70g / (feem ntau yog 0.5g /), tshwj xeeb gravity 1.26-1.31.Discoloration kub: 190-200 ℃, carbonization kub: 280-300 ℃.Nto nro: 42-56dyn / cm nyob rau hauv 2% aqueous tov.Nrog rau qhov nce ntawm methoxyl cov ntsiab lus, cov ntsiab lus gel poob qis, cov dej solubility nce, thiab cov dej ua haujlwm saum npoo kuj nce.HPMC muaj cov yam ntxwv ntawm thickening, salting, tsawg tshauv cov ntsiab lus, PH stability, dej tuav, seem stability, zoo heev zaj duab xis tsim thiab nws kim heev tsis kam mus rau enzyme, dispersity thiab cohesiveness.
Cov ntawv thov HPMC:
1. Cov ntsiav tshuaj txheej: HPMC siv los ua cov khoom siv zaj duab xis txheej hauv cov khoom npaj, tuaj yeem tsim cov yeeb yaj kiab tawv, du thiab zoo nkauj, siv cov concentration ntawm 2% -8%.Tom qab txheej txheej, kev ruaj ntseg ntawm tus neeg sawv cev rau lub teeb, cua sov thiab av noo yog nce;Tasteless thiab odorless, yooj yim rau noj, thiab HPMC pigment, tshuaj pleev thaiv hnub, lubricants thiab lwm yam zoo compatibility ntawm cov ntaub ntawv.Txheej txheej: dej los yog 30-80% ethanol kom yaj HPMC, nrog 3-6% tov, ntxiv cov khoom xyaw (xws li: av kub -80, castor roj, PEG400, talc, thiab lwm yam).
2. Enteric-soluble coating isolation layer isolation layer: on the surface of tablets and granules, HPMC txheej yog thawj zaug siv cov txheej hauv qab txheej cais, thiab tom qab ntawd coated nrog ib txheej ntawm HPMCP enteric-soluble khoom.HPMC zaj duab xis tuaj yeem txhim kho kev ruaj ntseg ntawm enteric-soluble txheej tus neeg sawv cev hauv kev cia.
3. Sustained-tso npaj: siv HPMC ua tus pore-inducing tus neeg sawv cev thiab tso siab rau ethyl cellulose li cov khoom siv pob txha, sustained-tso tawm cov ntsiav tshuaj ntev tuaj yeem ua tau.
4. Thickening agent thiab colloid tiv thaiv nplaum thiab qhov muag tee: HPMC rau thickening agent feem ntau siv concentration ntawm 0.45-1%.
5. Adhesive: HPMC raws li kev sib khi dav dav ntawm 2%-5%, siv los txhim kho kev ruaj ntseg ntawm hydrophobic nplaum, feem ntau siv concentration ntawm 0.5-1.5%.
6. Tus neeg saib xyuas ncua sijhawm, tus neeg saib xyuas kev tso tawm thiab tus neeg saib xyuas ncua.Tus neeg saib xyuas ncua sij hawm: qhov ntau npaum li cas ntawm tus neeg raug tshem tawm yog 0.5-1.5%.
7. Khoom noj khoom haus: HPMC ua tus neeg sawv cev thickening ntxiv rau ntau yam dej qab zib, khoom noj siv mis, condiments, khoom noj khoom haus, ua thickening agent, binder, emulsifier, suspension agent, stabilizer, water retention agent, excifer, etc.
8. Siv nyob rau hauv tshuaj pleev ib ce li adhesives, emulsifiers, film forming agents, thiab lwm yam.
Post lub sij hawm: Jan-14-2022