Hydroxypropyl Methyl Cellulose (HPMC), tseem paub los ntawm lub npe lag luam hypromellose, yog ib qho hluavtaws polymer muab los ntawm ntuj cellulose. Lub hauv paus ntawm cellulose rau kev tsim HPMC feem ntau yog ntoo pulp lossis paj rwb. Cov txheej txheem tsim khoom suav nrog kev hloov kho cov cellulose los ntawm etherification, qhia hydroxypropyl thiab methyl pawg mus rau cov pob txha cellulose.

Kev tsim tawm ntawm HPMC suav nrog ob peb kauj ruam:

1. Cellulose Extraction:
   • Cov cellulose yog tau los ntawm cov nroj tsuag, feem ntau ntoo pulp los yog paj rwb. Cov cellulose yog muab rho tawm thiab purified los ua cellulose pulp.
2. Alkalization:
   • Lub cellulose pulp yog kho nrog cov tshuaj alkaline, feem ntau yog sodium hydroxide (NaOH), kom qhib cov hydroxyl pawg ntawm cov saw cellulose.
3. Etherification:
   • Etherification yog kauj ruam tseem ceeb hauv kev tsim HPMC. Cov alkalized cellulose yog reacted nrog propylene oxide (rau hydroxypropyl pawg) thiab methyl chloride (rau methyl pawg) los qhia cov ether pawg mus rau hauv cov pob txha cellulose.
4. Neutralization thiab ntxuav:
   • Cov txiaj ntsig tau hloov kho cellulose, uas tam sim no yog Hydroxypropyl Methyl Cellulose, tau dhau los ua cov txheej txheem nruab nrab kom tshem tawm cov alkali seem. Tom qab ntawd nws yog ntxuav kom huv si kom tshem tawm impurities thiab by-products.
5. Drying thiab Milling:
   • Hloov kho cellulose yog qhuav kom tshem tawm cov dej noo ntau dhau thiab tom qab ntawd milled rau hauv cov hmoov zoo. Qhov loj me tuaj yeem tswj tau raws li daim ntawv thov npaj.

Cov khoom HPMC uas tau tshwm sim yog cov hmoov dawb los yog dawb dawb nrog cov qib sib txawv ntawm hydroxypropyl thiab methyl hloov pauv. Cov khoom tshwj xeeb ntawm HPMC, xws li nws cov solubility, viscosity, thiab lwm yam kev ua tau zoo, nyob ntawm seb qhov kev hloov pauv thiab cov txheej txheem tsim khoom.

Nws yog ib qho tseem ceeb uas yuav tsum nco ntsoov tias HPMC yog ib qho khoom siv hluav taws xob semi-synthetic, thiab thaum nws tau los ntawm cov cellulose ntuj, nws tau hloov kho tshuaj lom neeg tseem ceeb thaum lub sijhawm tsim khoom kom ua tiav nws cov khoom xav tau rau ntau yam kev siv.