Hydroxypropylmethylcellulose (HPMC) yog cellulose derivative feem ntau siv nyob rau hauv ntau yam kev lag luam, nrog rau cov kws kho mob, kev tsim kho thiab khoom noj khoom haus. Nws cov viscosity tuaj yeem sib txawv nyob ntawm seb yam xws li nws qhov hnyav molecular, qib kev hloov pauv, thiab kev daws teeb meem.
Taw qhia rau Hydroxypropyl Methylcellulose (HPMC)
Hydroxypropyl methylcellulose yog semi-synthetic polymer tau los ntawm kev hloov kho tshuaj ntawm cellulose. Vim nws cov khoom tshwj xeeb, nws tau dav siv los ua cov thickener, gelling tus neeg sawv cev, zaj duab xis qub thiab stabilizer hauv ntau daim ntawv thov.
Molecular qauv thiab muaj pes tsawg leeg
HPMC muaj cov pob txha cellulose nrog hydroxypropyl thiab methoxy substituents. Qhov degree ntawm kev hloov pauv (DS) yog hais txog qhov nruab nrab ntawm cov neeg hloov pauv hauv ib chav tsev anhydroglucose hauv cov saw cellulose. Tus nqi DS tshwj xeeb cuam tshuam rau lub cev thiab tshuaj lom neeg ntawm HPMC.
HPMC viscosity
Viscosity yog ib qho tseem ceeb parameter rau HPMC, tshwj xeeb tshaj yog nyob rau hauv daim ntawv thov uas siv nws cov thickening thiab gelling zog.
Lub viscosity ntawm HPMC cov kev daws teeb meem cuam tshuam los ntawm ntau yam:
1. Molecular hnyav
Qhov hnyav molecular ntawm HPMC cuam tshuam rau nws cov viscosity. Feem ntau, siab dua molecular hnyav HPMCs yuav tsim cov viscosity ntau dua. Muaj ntau qib sib txawv ntawm HPMC nyob rau hauv kev ua lag luam, txhua tus nrog nws tus kheej qhov hnyav molecular ntau yam.
2. Degree ntawm kev hloov pauv (DS)
Cov txiaj ntsig DS ntawm hydroxypropyl thiab methoxy pawg cuam tshuam rau kev solubility thiab viscosity ntawm HPMC. Cov txiaj ntsig DS siab dua feem ntau ua rau cov dej solubility nce ntxiv thiab cov kev daws teeb meem tuab dua.
3. Kev xav
Qhov concentration ntawm HPMC hauv kev daws yog qhov tseem ceeb cuam tshuam rau viscosity. Raws li cov concentration nce, viscosity feem ntau nce. Qhov kev sib raug zoo no feem ntau tau piav qhia los ntawm Krieger-Dougherty kab zauv.
4. Kub
Kub kuj tseem cuam tshuam qhov viscosity ntawm HPMC cov kev daws teeb meem. Feem ntau hais lus, viscosity txo qis thaum kub nce.
Cov chaw thov
Pharmaceuticals: HPMC feem ntau yog siv rau hauv cov tshuaj formulations, nrog rau cov ntsiav tshuaj thiab ophthalmic daws, qhov twg tswj kev tso tawm thiab viscosity tseem ceeb heev.
Kev tsim kho: Hauv kev tsim kho kev lag luam, HPMC yog siv los ua cov thickener hauv cov khoom siv cement los txhim kho kev ua haujlwm thiab kev tuav dej.
Kev lag luam khoom noj khoom haus: HPMC yog siv los ua cov thickener, stabilizer thiab emulsifier hauv cov ntawv thov zaub mov.
Lub viscosity ntawm hydroxypropyl methylcellulose yog cov cuab yeej nyuaj cuam tshuam los ntawm ntau yam xws li qhov hnyav molecular, qib kev hloov pauv, concentration thiab kub. Cov qib sib txawv ntawm HPMC muaj kom haum rau cov ntawv thov tshwj xeeb, thiab cov chaw tsim khoom muab cov ntaub ntawv qhia txog cov viscosity ntau ntawm txhua qib raws li ntau yam xwm txheej. Cov kws tshawb fawb thiab cov kws tsim qauv yuav tsum xav txog cov xwm txheej no los kho cov khoom ntawm HPMC kom ua tau raws li qhov xav tau ntawm lawv cov ntawv thov.
Post lub sij hawm: Jan-20-2024