Zaj duab xis txheej yog txheej txheem tseem ceeb hauv kev tsim tshuaj, nyob rau hauv ib txheej nyias ntawm polymer yog siv rau saum npoo ntawm cov ntsiav tshuaj lossis tshuaj ntsiav. Cov txheej no ua haujlwm rau ntau lub hom phiaj, suav nrog kev txhim kho cov tsos, saj npog ntsej muag, tiv thaiv cov khoom siv tshuaj nquag (API), tswj kev tso tawm, thiab ua kom yooj yim nqos. Hydroxypropyl Methylcellulose (HPMC) yog ib qho ntawm feem ntau siv polymers hauv zaj duab xis txheej vim nws ntau yam khoom.
1.Properties ntawm HPMC:
Hydroxypropyl Methylcellulose (HPMC) yog ib tug semi-synthetic polymer muab tau los ntawm cellulose. Nws yog tus yam ntxwv los ntawm nws cov dej-solubility, zaj duab xis-tsim muaj peev xwm, thiab zoo heev compatibility nrog ntau yam tshuaj cov khoom xyaw. Cov khoom ntawm HPMC tuaj yeem hloov kho los ntawm kev hloov pauv tsis xws li qhov hnyav molecular, qib hloov pauv, thiab viscosity.
Zaj duab xis tsim muaj peev xwm: HPMC muaj cov cuab yeej tsim cov yeeb yaj kiab zoo heev, ua kom muaj cov txheej txheem sib xws thiab cov txheej txheem du ntawm cov ntawv siv tshuaj.
Dej Solubility: HPMC nthuav tawm cov dej-solubility, tso cai rau kev sib cais ntawm cov polymer hauv cov tshuaj aqueous thaum txheej txheem txheej. Cov cuab yeej no ua kom cov khoom sib txawv ntawm cov polymer thiab ua kom yooj yim tsim cov txheej txheej homogeneous.
Adhesion: HPMC qhia tau zoo adhesion rau saum npoo ntawm cov ntsiav tshuaj lossis tshuaj ntsiav, ua rau cov coatings ruaj khov uas ua raws li cov substrate.
Barrier Properties: HPMC muab kev thaiv kev tiv thaiv ib puag ncig xws li ya raws, oxygen, thiab lub teeb, yog li tiv thaiv kev ncaj ncees ntawm daim ntawv ntau npaum thiab txhim khu kev ruaj ntseg.
2.Formulation Considerations:
Hauv kev tsim cov yeeb yaj kiab-txheej txheej siv HPMC, ntau yam yuav tsum tau txiav txim siab kom ua tiav cov yam ntxwv ntawm cov txheej txheem thiab kev ua haujlwm.
Polymer Concentration: Lub concentration ntawm HPMC nyob rau hauv cov txheej txheem tshuaj influences lub thickness thiab mechanical zog ntawm zaj duab xis. Ntau cov polymer concentrations ua rau cov txheej tuab nrog cov khoom thaiv kev txhim kho.
Plasticizers: Ntxiv cov yas yas xws li polyethylene glycol (PEG) los yog propylene glycol (PG) tuaj yeem txhim kho qhov yooj thiab elasticity ntawm txheej, ua rau nws tsis nkig thiab tiv taus ntau dua rau kev tawg.
Cov kuab tshuaj: Kev xaiv cov kuab tshuaj uas tsim nyog yog qhov tseem ceeb los xyuas kom meej qhov solubility ntawm HPMC thiab tsim cov yeeb yaj kiab kom raug. Cov kuab tshuaj feem ntau muaj xws li dej, ethanol, isopropanol, thiab cov khoom sib xyaw.
Pigments thiab Opacifiers: Kev koom ua ke ntawm cov pigments thiab opacifiers rau hauv cov txheej txheem txheej tuaj yeem faib xim, txhim kho qhov tsos, thiab muab kev tiv thaiv lub teeb rau cov tshuaj rhiab heev.
3.Kev siv ntawm HPMC hauv Zaj Duab Xis:
HPMC-based coatings pom cov ntawv siv dav hauv kev lag luam tshuaj thiab tshuaj noj vim lawv muaj ntau yam thiab tsim nyog rau ntau hom tshuaj.
Kev Tso Tawm Tam Sim No: HPMC txheej tuaj yeem siv los muab cov tshuaj tso tawm tam sim los ntawm kev tswj cov kev sib cais thiab kev sib cais ntawm cov ntsiav tshuaj lossis tshuaj ntsiav.
Hloov Kho Cov Txheej Txheem Tshaj Tawm: HPMC-raws li cov qauv tsim feem ntau yog ua haujlwm hauv cov ntaub ntawv hloov kho tso tawm, suav nrog cov ntawv txuas ntxiv-tso thiab enteric-coated formulations. Los ntawm kev hloov kho cov viscosity thiab thickness ntawm txheej, qhov kev tso tawm profile ntawm cov tshuaj tuaj yeem raug kho kom ua tiav kev tso tawm los yog lub hom phiaj.
Taste Masking: HPMC coatings tuaj yeem npog qhov tsis hnov tsw ntawm cov tshuaj, txhim kho kev ua raws li tus neeg mob thiab kev lees paub ntawm qhov ncauj ntau npaum li cas.
Kev Tiv Thaiv Kev Nyab Xeeb: HPMC txheej muaj kev tiv thaiv zoo noo noo, tshwj xeeb tshaj yog rau cov tshuaj hygroscopic uas ua rau degradation thaum raug cov dej noo.
Stability Enhancement: HPMC txheej muab kev tiv thaiv kev tiv thaiv ib puag ncig, yog li txhim kho kev ruaj ntseg thiab txee lub neej ntawm cov khoom siv tshuaj.
Hydroxypropyl Methylcellulose (HPMC) plays lub luag haujlwm tseem ceeb hauv daim ntawv thov txheej txheej hauv kev lag luam tshuaj. Nws cov khoom tshwj xeeb, suav nrog kev muaj peev xwm ua yeeb yaj kiab, dej solubility, adhesion, thiab barrier zog, ua rau nws yog qhov kev xaiv zoo tshaj plaws rau kev tsim cov txheej txheej nrog ntau yam kev ua haujlwm. Los ntawm kev nkag siab txog kev txiav txim siab txog kev tsim thiab kev siv ntawm HPMC hauv zaj duab xis txheej, cov chaw tsim tshuaj tuaj yeem tsim cov ntawv ntau npaum nrog kev ua tau zoo, kev ruaj ntseg, thiab kev lees paub ntawm tus neeg mob.
Post lub sij hawm: Mar-07-2024