Zaj duab xis txheej yog cov txheej txheem tseem ceeb hauv cov tshuaj lag luam, qhov twg txheej txheej ntawm polymer yog thov rau saum cov ntsiav tshuaj lossis tshuaj ntsiav. Cov txheej no pab ntau lub hom phiaj, suav nrog kev txhim kho cov tsos, tiv thaiv cov khoom noj muaj zog (API), tswj tau kev nqos. HydroxyPropyyl Metylcellulose (HPMC) yog ib qho ntawm feem ntau dav siv cov polymers hauv zaj duab xis txheej vim nws cov khoom muaj ntau yam.
1.propoperties ntawm HPMC:
HydroxyPropyyl methylcellulose (HPMC) yog ib nrab hluavtaws polymer muab tau los ntawm cellulose. Nws yog tus cwj pwm los ntawm nws cov dej-solubility, ua yeeb yaj kiab ua yeeb yam, thiab kev sib haum zoo nkauj nrog ntau cov khoom xyaw. Cov khoom ntawm HPMC tuaj yeem raug tsim kho los ntawm kev hloov kho tsis zoo xws li qhov hnyav molecular, qib hloov pauv, thiab viscosity.
Zaj duab xis tsim muaj peev xwm: HPMC muaj cov yeeb yaj kiab zoo tshaj plaws, ua kom cov txheej txheem ntawm cov khaub ncaws hnav thiab du ntawm cov npoo hluav taws xob.
Dej solubility: HPMC cov khoom ua pov thawj dej-solubility, tso cai rau kev sib cais ntawm cov kev daws teeb meem thaum ua cov txheej txheem txheej txheej. Cov cuab yeej no ua kom cov kev faib tawm tsis sib raug zoo ntawm cov polymer thiab tswj kev tsim cov homogeneous txheej.
Adhesion: HPMC pom cov nplaum zoo rau saum npoo ntawm cov ntsiav tshuaj lossis cov tsiav tshuaj lossis cov tsiav tshuaj, ua rau cov txheej qub uas ua raws li lub substrate.
Cov Khoom Siv Hluav Taws Xob: HPMC muab cov teeb meem tawm tsam ib puag ncig ib puag ncig xws li noo noo, oxygen, thiab teeb pom kev ncaj ncees ntawm daim ntawv ntau npaum li cas thiab txhim kho kev ruaj ntseg.
2.Cformulation txiav txim siab:
Hauv kev tsim cov yeeb yaj kiab-txheej daws daws cov lus HPMC, ntau yam yuav tsum tau txiav txim siab ua kom tiav cov yam ntxwv uas xav tau.
Polymer concentration: kev xav ntawm HPMC nyob rau hauv lub coating daws cuam tshuam cov tuab thiab cov neeg kho khoom ntawm zaj duab xis. Cov polymer polymer ntau dua hauv cov txheej txheej tuab nrog cov teeb meem txhim kho cov khoom.
Cov hnab yas: ntxiv cov plaskas xws li polyethylene glycol (peg) lossis propylene glycol (ua kom muaj nkig me ntsis thiab tiv thaiv kom tawg.
Cov kuab tshuaj: xaiv cov kuab tshuaj uas tsim nyog yog qhov tseem ceeb los xyuas kom cov solubility ntawm HPMC thiab kev ua yeeb yaj kiab zoo tsim. Cov kuab tshuaj uas suav nrog dej, ethanol, isopropanol, thiab sib xyaw.
Pigments thiab opacifior: koom ua ke ntawm cov pigments thiab opacifiers rau txheej txheej ua kom muaj cov xim, txhim kho kev nyab xeeb, thiab muab kev tiv thaiv lub teeb rau cov tshuaj tiv thaiv.
3. Cov npog ntawm HPMC hauv Zaj Duab Xis Txheej:
HPMC-based txheej txheem pom cov ntawv thov dav dav hauv kev lag luam thiab nutraceutical thiab nutraceutical kev lag luam vim lawv cov versatility thiab haum rau ntau yam khoom noj.
Siv cov txheej txheej tam sim no: HPMC txheej txheej tuaj yeem siv los muab cov yeeb tshuaj tam sim ntawd los ntawm kev tswj cov kev ua kom tsis tu ncua thiab cov tshuaj ntsiav.
Hloov Pastings: Kev ua haujlwm HPMC yog cov nquag ua haujlwm hauv kev hloov pauv cov tshuaj, suav nrog kev tso tawm exalmication thiab enteric-coated formulations. Los ntawm kev kho cov viscososity thiab tuab ntawm txheej, cov tso tawm ntawm cov tshuaj tuaj yeem ua kom tiav kom ua tiav lossis tau tso tawm.
Kev saj ntsej muag: HPMC txheej tuaj yeem npog cov tshuaj tsis txaus siab, txhim kho cov ntaub ntawv ntawm cov tshuaj.
Kev tiv thaiv noo noo: HPMC txheej muaj kev tiv thaiv noo noo, tshwj xeeb rau cov tshuaj Hygroscopic tau sib xws thaum raug cov dej noo.
Kev ruaj khov txhim kho: HPMC tsho tiv thaiv tau muab cov kev tiv thaiv kev tiv thaiv kev tiv thaiv ib puag ncig, yog li txhim kho lub neej ruaj khov thiab lub cev ntawm cov tshuaj.
HydroxyPropyyl methylcellose (HPMC) ua lub luag haujlwm tseem ceeb hauv zaj kev thov ua yeeb yaj kiab hauv kev lag luam. Nws cov khoom tshwj xeeb, suav nrog kev ua yeeb yaj kiab ua yeeb yam, kev xaiv dej, thiab kev xaiv qhov zoo tshaj plaws rau cov txheej txheem pleev xim nrog ntau yam kev ua haujlwm. Los ntawm kev nkag siab cov qauv kev xav thiab cov ntawv thov ntawm HPMC hauv zaj duab xis, chaw tsim tshuaj paus tuaj yeem tsim kho cov ntaub ntawv nrog kev ua tau zoo, ruaj khov, thiab tus neeg mob kev lees paub.
Lub Sijhawm Post: Mar-07-2024