Hydroxypropylmethylcellulose (HPMC) thiab carboxymethylcellulose (CMC) yog ob hom polymers siv rau hauv qhov muag poob formulations, feem ntau siv los txo cov tsos mob ntawm qhov muag qhuav. Txawm hais tias lawv sib koom qee qhov sib xws, ob lub tebchaw no muaj qhov sib txawv hauv lawv cov qauv tshuaj, cov khoom, kev ua haujlwm, thiab kev siv tshuaj kho mob.
Hydroxypropyl methylcellulose (HPMC) qhov muag tee:
1.Chemical qauv:
HPMC yog cov khoom siv hluav taws xob ntawm cov cellulose, lub ntuj polymer pom nyob rau hauv cov phab ntsa ntawm cov nroj tsuag.
Hydroxypropyl thiab methyl pawg tau nkag mus rau hauv cov qauv cellulose, muab HPMC cov khoom tshwj xeeb.
2. Viscosity thiab rheology:
HPMC qhov muag tee feem ntau muaj viscosity ntau dua li lwm cov tshuaj pleev qhov muag.
Qhov nce viscosity pab cov tee nyob rau ntawm lub qhov muag ntev, muab kev pab ntev.
3. Mechanism ntawm kev ua:
HPMC tsim cov txheej txheem tiv thaiv thiab lubricating ntawm lub ntsej muag, txo kev sib txhuam thiab txhim kho kua muag zaj duab xis stability.
Nws pab txo cov tsos mob ntawm qhov muag qhuav los ntawm kev tiv thaiv cov kua muag ntau dhau.
4. Daim ntawv thov kev kho mob:
HPMC qhov muag tee feem ntau yog siv los kho qhov muag qhuav.
Lawv kuj tau siv rau hauv kev phais ophthalmic thiab kev phais kom tswj cov pob txha hydration.
5. Qhov zoo:
Vim lub viscosity siab dua, nws tuaj yeem txuas ntxiv lub sijhawm nyob ntawm qhov chaw ocular.
Cov tsos mob ntawm qhov muag qhuav zoo thiab muab kev nplij siab.
6. Qhov tsis zoo:
Qee tus neeg yuav pom qhov muag tsis pom kev tam sim ntawd tom qab instillation vim nce viscosity.
Carboxymethylcellulose (CMC) qhov muag tee:
1.Chemical qauv:
CMC yog lwm cellulose derivative hloov nrog carboxymethyl pawg.
Kev taw qhia ntawm pawg carboxymethyl txhim kho cov dej solubility, ua CMC cov dej-soluble polymer.
2. Viscosity thiab rheology:
CMC qhov muag tee feem ntau muaj viscosity qis dua piv rau HPMC qhov muag tee.
Qhov qis viscosity tso cai rau kom yooj yim instillation thiab sai kis thoob plaws lub qhov muag nto.
3. Mechanism ntawm kev ua:
CMC ua raws li cov roj nplua nyeem thiab humectant, txhim kho kua muag yeeb yaj kiab stability.
Nws pab txo cov tsos mob ntawm qhov muag qhuav los ntawm kev txhawb nqa cov dej noo ntawm lub qhov muag.
4. Daim ntawv thov kev kho mob:
CMC qhov muag tee yog dav siv los txo cov tsos mob ntawm qhov muag qhuav.
Lawv feem ntau pom zoo rau cov neeg uas muaj mob me mus rau nruab nrab qhov muag qhuav.
5. Qhov zoo:
Vim nws cov viscosity tsawg, nws kis tau sai thiab yooj yim rau drip.
Ua tau zoo thiab sai sai tshem tawm cov tsos mob ntawm qhov muag qhuav.
6. Qhov tsis zoo:
Kev siv tshuaj ntau zaus yuav tsum tau muab piv rau ntau dua viscosity formulations.
Qee qhov kev npaj yuav muaj lub sijhawm luv luv ntawm kev ua ntawm lub qhov muag.
Kev sib piv:
1. Viscosity:
HPMC muaj viscosity ntau dua, muab kev pab ntev dua thiab kev tiv thaiv ntau dua.
CMC muaj qis viscosity, tso cai rau kev sib kis sai dua thiab yooj yim dua instillation.
2. Lub sijhawm ua haujlwm:
HPMC feem ntau muab lub sijhawm ntev ntawm kev ua haujlwm vim nws cov viscosity siab dua.
CMC tej zaum yuav tsum tau txhaj tshuaj ntau zaus, tshwj xeeb tshaj yog thaum muaj qhov muag qhuav heev.
3. Kev nplij siab ntawm tus neeg mob:
Qee tus neeg yuav pom tias HPMC qhov muag poob thaum xub thawj ua rau qhov muag tsis pom kev ib ntus vim lawv cov viscosity siab dua.
CMC qhov muag tee feem ntau ua tau zoo thiab ua rau tsis tshua pom qhov muag pom.
4. Cov lus pom zoo kho mob:
HPMC feem ntau pom zoo rau cov neeg uas muaj mob hnyav rau qhov muag qhuav.
CMC feem ntau yog siv rau qhov muag me me mus rau nruab nrab qhov muag qhuav thiab rau cov neeg uas nyiam cov mis mos viscous.
Hydroxypropylmethylcellulose (HPMC) thiab carboxymethylcellulose (CMC) qhov muag tee yog ob qho kev xaiv tseem ceeb rau kev kho mob qhov muag qhuav. Qhov kev xaiv ntawm ob yog nyob ntawm tus neeg mob tus kheej nyiam, qhov hnyav ntawm qhov muag qhuav, thiab lub sijhawm xav tau ntawm kev ua. HPMC qhov viscosity siab dua muab kev tiv thaiv ntev dua, thaum CMC qhov viscosity qis dua muab kev pab sai thiab tej zaum yuav yog thawj qhov kev xaiv rau cov neeg uas tsis pom kev tsis pom kev. Cov kws kho qhov muag thiab cov kws kho qhov muag feem ntau xav txog cov xwm txheej no thaum xaiv cov tshuaj pleev qhov muag uas tsim nyog tshaj plaws rau lawv cov neeg mob, tsim los ua kom zoo rau kev nplij siab thiab zoo txo qhov muag qhuav.
Post lub sij hawm: Dec-25-2023