Carbomer thiab hydroxyethylcellulose (HEC) yog ob qho tib si siv cov khoom xyaw hauv ntau qhov kev lag luam, tshwj xeeb tshaj yog hauv cov tshuaj pleev ib ce, tshuaj, thiab cov khoom tu tus kheej. Txawm hais tias lawv cov ntawv thov zoo sib xws li cov neeg ua kom tuab thiab cov stabilizers, lawv muaj cov tshuaj sib txawv, cov khoom, thiab kev siv.
1. Tshuaj muaj pes tsawg leeg:
Carbomer: Carbomers yog hluavtaws siab molecular hnyav polymers ntawm acrylic acid cross-linked nrog polyalkenyl ethers los yog divinyl glycol. Lawv feem ntau yog tsim los ntawm cov tshuaj tiv thaiv polymerization.
Hydroxyethylcellulose: Hydroxyethylcellulose, ntawm qhov tod tes, yog ib qho derivative ntawm cellulose, ib txwm tshwm sim polymer. Nws yog tsim los ntawm kev kho cellulose nrog sodium hydroxide thiab ethylene oxide los qhia cov pab pawg hydroxyethyl mus rau cellulose qaum.
2. Molecular Structure:
Carbomer: Carbomers muaj ib tug branched molecular qauv vim lawv cross-linked xwm. Cov ceg no txhawb nqa lawv lub peev xwm los tsim ib qho kev sib txuas ntawm peb sab thaum hydrated, ua rau kom muaj zog thickening thiab gelling zog.
Hydroxyethylcellulose: Hydroxyethylcellulose khaws cov qauv linear ntawm cellulose, nrog hydroxyethyl pawg txuas mus rau cov piam thaj hauv cov khoom siv polymer. Cov qauv linear no cuam tshuam nws tus cwj pwm raws li cov thickener thiab stabilizer.
3. Solubility:
Carbomer: Carbomers feem ntau muab rau hauv daim ntawv hmoov thiab yog insoluble hauv dej. Txawm li cas los xij, lawv tuaj yeem o thiab hydrate hauv cov tshuaj aqueous, tsim cov gels pob tshab lossis cov kua nplaum tawg.
Hydroxyethylcellulose: Hydroxyethylcellulose kuj tau muab rau hauv daim ntawv hmoov tab sis yog yooj yim soluble hauv dej. Nws dissolves los ua kom meej meej los yog me ntsis turbid daws, nyob ntawm seb cov concentration thiab lwm yam formulation Cheebtsam.
4. Thickening Properties:
Carbomer: Carbomers yog cov thickeners zoo heev thiab tuaj yeem tsim viscosity nyob rau hauv ntau hom formulations, xws li cream, gels, thiab lotions. Lawv muab cov khoom zoo heev tshem tawm thiab feem ntau siv los tswj cov emulsions.
Hydroxyethylcellulose: Hydroxyethylcellulose kuj ua hauj lwm raws li ib tug thickener tab sis muaj ib tug txawv rheological cwj pwm piv rau carbomers. Nws imparts pseudoplastic los yog shear-thinning ntws mus rau formulations, lub ntsiab lus nws viscosity txo nyob rau hauv shear stress, ua kom yooj yim daim ntawv thov thiab kis.
5. Compatibility:
Carbomer: Carbomers tau sib xws nrog ntau yam khoom xyaw kom zoo nkauj thiab qib pH. Txawm li cas los xij, lawv yuav xav tau kev ua kom tsis zoo nrog alkalis (xws li, triethanolamine) kom ua tiav qhov zoo tshaj plaws thickening thiab gelling zog.
Hydroxyethylcellulose: Hydroxyethylcellulose yog sib xws nrog ntau cov kuab tshuaj thiab cov khoom xyaw tshuaj pleev ib ce. Nws ruaj khov tshaj pH dav dav thiab tsis tas yuav tsum tau nruab nrab rau thickening.
6. Cov cheeb tsam thov:
Carbomer: Carbomers nrhiav kev siv ntau hauv cov khoom siv tu tus kheej xws li cream, tshuaj pleev, gels, thiab cov tshuaj tu plaub hau. Lawv kuj tau siv hauv cov khoom lag luam xws li tshuaj pleev gels thiab tshuaj kho qhov muag.
Hydroxyethylcellulose: Hydroxyethylcellulose feem ntau ua haujlwm hauv cov tshuaj pleev ib ce thiab kho tus kheej, suav nrog tshuaj zawv plaub hau, tshuaj kho mob, ntxuav lub cev, thiab tshuaj txhuam hniav. Nws kuj yog siv nyob rau hauv kev siv tshuaj, tshwj xeeb tshaj yog nyob rau hauv tshuaj pleev ib ce formulations.
7. Cov yam ntxwv ntawm kev xav:
Carbomer: Carbomer gels feem ntau nthuav tawm ib qho kev ntxhib los mos thiab lub ntsej muag zoo nkauj, nthuav tawm qhov kev xav tau zoo rau cov qauv tsim. Txawm li cas los xij, lawv yuav hnov me ntsis tacky lossis nplaum thaum thov hauv qee kis.
Hydroxyethylcellulose: Hydroxyethylcellulose imparts ib tug txhob lo lo ntxhuav thiab tsis nplaum rau formulations. Nws tus cwj pwm shear-thinning pab txhawb kom yooj yim kis tau thiab nqus tau, txhim kho cov neeg siv kev paub.
8. Kev txiav txim siab raws cai:
Carbomers: Carbomers feem ntau lees paub tias muaj kev nyab xeeb (GRAS) los ntawm cov cai tswj hwm thaum siv raws li kev tsim khoom zoo (GMP). Txawm li cas los xij, cov kev cai tshwj xeeb yuav sib txawv nyob ntawm daim ntawv thov thiab thaj chaw thaj chaw.
Hydroxyethylcellulose: Hydroxyethylcellulose kuj suav hais tias muaj kev nyab xeeb rau kev siv tshuaj pleev ib ce thiab tshuaj, nrog kev pom zoo los ntawm cov tub ceev xwm. Kev ua raws li cov cai thiab cov lus qhia uas siv tau yog qhov tseem ceeb rau kev ua kom cov khoom muaj kev nyab xeeb thiab kev ua tau zoo.
Thaum ob qho tib si carbomer thiab hydroxyethylcellulose ua cov thickeners zoo thiab stabilizers nyob rau hauv ntau yam formulations, lawv txawv nyob rau hauv cov nqe lus ntawm tshuaj muaj pes tsawg leeg, molecular qauv, solubility, thickening zog, compatibility, daim ntawv thov cheeb tsam, sensory yam ntxwv, thiab kev tswj xyuas. Kev nkag siab txog qhov sib txawv no yog qhov tseem ceeb rau cov neeg tsim qauv los xaiv cov khoom tsim nyog tshaj plaws rau lawv cov khoom tshwj xeeb thiab cov qauv kev ua haujlwm.
Lub sij hawm xa tuaj: Plaub Hlis-18-2024