Hydroxypropyl Methylcellulose (HPMC) yog ntau yam polymer uas pom cov ntawv siv dav hauv ntau lub lag luam, suav nrog tshuaj, khoom noj, kev tsim kho, thiab tshuaj pleev ib ce. Nws cov khoom tshwj xeeb ua rau nws tseem ceeb hauv cov txheej txheem uas xav tau kev hloov kho viscosity, tsim zaj duab xis, khi, thiab txhim kho kev ruaj ntseg. Kev nkag siab txog qhov muaj pes tsawg leeg, kev tsim khoom, cov khoom siv, thiab kev siv ntawm HPMC yog qhov tseem ceeb rau nws txoj kev siv tau zoo.
1.Composition ntawm HPMC
HPMC yog ib tug semi-synthetic polymer muab los ntawm cellulose, ib txwm tshwm sim polysaccharide pom nyob rau hauv lub cell phab ntsa ntawm cov nroj tsuag. Cov txheej txheem tsim khoom suav nrog kev kho cellulose nrog alkali los tsim cov alkali cellulose, ua raws li etherification nrog propylene oxide thiab methyl chloride. Qhov kev hloov kho tshuaj no ua rau muaj kev qhia txog hydroxypropyl thiab methoxy hloov mus rau cellulose qaum, yielding HPMC.
Qib ntawm kev hloov pauv (DS) ntawm hydroxypropyl thiab methoxy pawg txiav txim siab cov yam ntxwv ntawm HPMC, suav nrog kev solubility, gelation, thiab cov yeeb yaj kiab tsim cov yam ntxwv. Feem ntau, HPMC qib nrog cov txiaj ntsig DS siab dua tuaj yeem ua rau muaj kev solubility hauv dej thiab txhim kho gelation peev xwm.
2.Properties ntawm HPMC
Dej Solubility: HPMC yog soluble nyob rau hauv dej txias, tsim kom meej, viscous daws. Lub solubility tuaj yeem raug kho los ntawm kev kho cov degree ntawm kev hloov pauv, qhov hnyav molecular, thiab kub.
Zaj duab xis tsim: HPMC tuaj yeem tsim cov yeeb yaj kiab hloov tau yooj yim thiab pob tshab thaum ziab. Cov yeeb yaj kiab no muaj cov khoom thaiv zoo heev, ua rau lawv tsim nyog rau kev siv txheej txheej hauv kev lag luam tshuaj thiab zaub mov.
Kev hloov kho viscosity: HPMC nthuav tawm cov cwj pwm pseudoplastic, uas nws cov viscosity txo qis nrog nce shear npaum li cas. Cov cuab yeej no yog siv nyob rau hauv ntau yam formulations los tswj tus cwj pwm khiav thiab rheological yam ntxwv.
Thermal Stability: HPMC qhia kev ruaj ntseg nyob rau hauv ntau qhov kub thiab txias, ua rau nws haum rau cov ntawv thov uas yuav tsum tau ua kom sov los yog raug rau qhov kub siab.
Chemical Inertness: HPMC yog tshuaj inert, sib xws nrog ntau yam additives, excipients, thiab cov khoom xyaw nquag siv hauv cov tshuaj thiab zaub mov formulations.
3.Synthesis ntawm HPMC
Lub synthesis ntawm HPMC muaj ob peb kauj ruam:
Kev kho Alkali: Cellulose yog kho nrog alkali, xws li sodium hydroxide, los tsim alkali cellulose.
Etherification: Alkali cellulose yog reacted nrog propylene oxide los qhia hydroxypropyl pawg mus rau cellulose qaum.
Methylation: Cov hydroxypropylated cellulose tau kho ntxiv nrog methyl chloride los qhia methoxy pawg, yielding HPMC.
Purification: Qhov tshwm sim HPMC yog purified kom tshem tawm cov khoom los ntawm cov khoom thiab impurities, ua kom cov khoom zoo thiab sib xws.
4.Kev siv ntawm HPMC
Kev Lag Luam Pharmaceutical: HPMC tau siv dav los ua cov khoom siv tshuaj hauv cov tshuaj ntsiav tshuaj, qhov twg nws ua haujlwm raws li kev sib khi, kev sib cais, thiab kev tswj-tso tus neeg sawv cev. Nws kuj yog ua hauj lwm hauv cov tshuaj kho qhov muag, tshuaj pleev ib ce, thiab qhov ncauj tshem tawm vim nws cov biocompatibility thiab mucoadhesive zog.
Kev Lag Luam Khoom Noj: Hauv kev lag luam khoom noj khoom haus, HPMC ua hauj lwm ua cov thickener, stabilizer, thiab emulsifier nyob rau hauv ntau yam khoom, nrog rau cov kua ntses, hnav khaub ncaws, thiab lwm yam khoom noj siv mis. Nws kuj tseem siv rau hauv gluten-dawb ci ua tus neeg saib xyuas cov khoom siv thiab cov khoom ua kom dej noo.
Kev Tsim Kho Kev Lag Luam: HPMC yog ib qho tseem ceeb ntxiv hauv cov cement-based mortars, plasters, thiab pobzeb adhesives. Nws txhim kho kev ua haujlwm, dej tuav, thiab adhesion, pab txhawb kev ua haujlwm tag nrho thiab ua haujlwm ntev ntawm cov khoom siv.
Cov Khoom Siv Kho Tus Kheej: HPMC tau muab tso rau hauv cov tshuaj pleev ib ce, cov khoom tu tawv nqaij, thiab cov tshuaj tu plaub hau rau nws cov yeeb yaj kiab tsim, thickening, thiab emulsifying zog. Nws imparts kev zoo nkauj, stability, thiab sensory cwj pwm rau lotions, cream, thiab gels.
Txheej thiab ntim: HPMC-raws li txheej yog siv rau cov tshuaj ntsiav tshuaj thiab tshuaj ntsiav los txhim kho kev nqos tau, lub ntsej muag saj, thiab muab kev tiv thaiv noo noo. HPMC cov yeeb yaj kiab kuj tseem siv rau hauv ntim khoom noj raws li cov khoom siv los yog cov khoom thaiv kev tiv thaiv ya raws thiab oxygen.
Hydroxypropyl Methylcellulose (HPMC) yog ib qho khoom siv polymer nrog ntau hom kev siv thoob plaws hauv kev lag luam. Nws qhov tshwj xeeb ua ke ntawm cov khoom, suav nrog cov dej solubility, tsim zaj duab xis, viscosity hloov kho, thiab tshuaj inertness, ua rau nws indispensable nyob rau hauv kws tshuaj, khoom noj khoom haus, kev tsim kho, thiab cov khoom tu tus kheej. Kev nkag siab txog kev sib xyaw, kev sib txuas, cov khoom siv, thiab kev siv ntawm HPMC yog qhov tseem ceeb rau cov neeg tsim khoom thiab cov tuam txhab nrhiav kev siv nws cov txiaj ntsig hauv kev tsim khoom thiab kev tsim kho tshiab.
HPMC qhov tseem ceeb nyob rau hauv nws ntau yam, kev ua haujlwm, thiab kev pab txhawb rau kev txhim kho kev ua tau zoo, kev ruaj ntseg, thiab kev xav ntawm ntau yam khoom hauv ntau qhov chaw, ua rau nws muaj txiaj ntsig zoo hauv cov qauv tsim thiab kev siv niaj hnub no.
Post lub sij hawm: Feb-29-2024