Hydroxypropylmethylcellulose (HPMC) yog ib qho khoom siv polymer uas siv dav hauv kev lag luam tshuaj. Nws belongs rau pawg cellulose ether thiab yog muab los ntawm natural cellulose. HPMC yog synthesized los ntawm kev kho cellulose nrog propylene oxide thiab methyl chloride, uas ua rau cov tebchaw nrog txhim kho solubility thiab lwm yam khoom uas xav tau. Cov tshuaj excipient no tau siv dav hauv kev txhim kho thiab tsim cov ntawv ntau npaum li cas, suav nrog cov ntsiav tshuaj, tshuaj ntsiav, tshuaj kho qhov muag thiab tswj-tso tshuaj xa cov tshuab.
Taw qhia rau hydroxypropyl methylcellulose:
Chemical structure thiab properties:
Hydroxypropyl methylcellulose yog semi-synthetic, inert, dej-soluble polymer. Nws cov qauv tshuaj muaj xws li hydroxypropyl thiab methoxy pawg txuas mus rau lub pob txha cellulose. Qhov kev faib ua feem ntawm cov hloov pauv no tuaj yeem sib txawv, ua rau cov qib sib txawv ntawm HPMC nrog cov khoom sib txawv. Cov qauv hloov pauv cuam tshuam rau qhov tsis xws li viscosity, solubility, thiab gel zog.
Kev tsim khoom:
Kev tsim tawm ntawm HPMC suav nrog etherification ntawm cellulose nrog propylene oxide thiab methyl chloride. Lub degree ntawm kev hloov pauv (DS) ntawm hydroxypropyl thiab methoxy pawg tuaj yeem tswj tau thaum lub sijhawm sib txuas, tso cai rau kev txiav cov khoom HPMC rau cov kev cai tsim tshuaj tshwj xeeb.
Kev siv hauv kev lag luam kws tshuaj:
Binders nyob rau hauv cov ntsiav tshuaj formulations:
HPMC yog dav siv los ua cov ntawv khi hauv cov ntsiav tshuaj. Nws cov khoom sib txuas pab hauv compressing cov hmoov rau hauv cov ntsiav tshuaj. Kev tswj hwm kev tso tawm ntawm cov khoom xyaw tshuaj nquag (APIs) tuaj yeem ua tiav los ntawm kev siv cov qib tshwj xeeb ntawm HPMC nrog cov qib viscosity tsim nyog thiab hloov pauv.
Film coating agent:
HPMC yog siv los ua cov yeeb yaj kiab txheej rau cov ntsiav tshuaj thiab granules. Nws muab cov txheej tiv thaiv zoo sib xws uas txhim kho cov tsos, saj daim npog qhov ncauj thiab kev ruaj ntseg ntawm cov ntawv ntau npaum. Tsis tas li ntawd, HPMC-raws li txheej txheej tuaj yeem hloov kho cov yeeb yaj kiab tso tawm.
Sustained thiab tswj kev tso tawm:
Lub hydrophilic xwm ntawm no polymer ua rau nws haum rau siv nyob rau hauv sustained- thiab tswj-tso formulations. HPMC matrix tso cai rau kev tswj cov tshuaj tso tawm nyob rau lub sijhawm ntev, txhim kho kev ua raws li tus neeg mob thiab txo cov koob tshuaj ntau zaus.
Ophthalmic npaj:
Nyob rau hauv cov tshuaj ophthalmic formulations, HPMC yog siv los ua kom cov viscosity ntawm qhov muag tee, yog li muab lub sij hawm nyob rau hauv lub ocular nto. Qhov no txhim kho cov tshuaj bioavailability thiab kho kev ua tau zoo.
Thickening stabilizer:
HPMC yog siv los ua cov thickener thiab stabilizer nyob rau hauv cov kua thiab semi-solid formulations xws li gels, cream thiab suspensions. Nws imparts viscosity rau cov formulations thiab txhim kho lawv tag nrho rheological zog.
Cov yam ntxwv tseem ceeb ntawm HPMC:
Solubility:
HPMC yog soluble hauv dej thiab tsim cov kua ntshiab, tsis muaj xim. Tus nqi ntawm kev sib cais yog cuam tshuam los ntawm qib kev hloov pauv thiab qib viscosity.
viscosity:
Lub viscosity ntawm HPMC cov kev daws teeb meem yog qhov tseem ceeb hauv kev txiav txim siab lawv cov kev ua tau zoo hauv ntau daim ntawv thov. Cov qib sib txawv muaj nyob nrog cov viscosities sib txawv, tso cai rau kev tswj xyuas meej ntawm cov khoom rheological ntawm cov qauv.
Thermal gelation:
Qee qib ntawm HPMC muaj cov khoom siv thermogelling, tsim cov gels ntawm qhov kub thiab txias. Cov cuab yeej no yog siv los tsim cov txheej txheem kub-rhiab heev.
compatibility:
HPMC yog sib xws nrog ntau hom tshuaj excipients thiab APIs, ua rau nws yog thawj qhov kev xaiv rau formulators. Nws tsis hnov mob nrog lossis degrade cov khoom xyaw nquag.
Cov kev sib tw thiab kev txiav txim siab:
Hygroscopicity:
HPMC yog hygroscopic, txhais tau tias nws absorbs noo noo los ntawm ib puag ncig. Qhov no cuam tshuam rau kev ruaj ntseg thiab cov tsos ntawm cov formulation, yog li yuav tsum tau khaws cia kom zoo.
Compatibility nrog rau lwm yam excipients:
Txawm hais tias feem ntau sib xws, cov neeg tsim qauv yuav tsum xav txog qhov sib raug ntawm HPMC nrog rau lwm cov khoom siv kom tsis txhob muaj kev cuam tshuam uas yuav cuam tshuam rau kev tsim cov qauv.
Qhov cuam tshuam ntawm kev sib cais nkhaus:
Kev xaiv ntawm qib HPMC tuaj yeem cuam tshuam rau qhov kev sib cais ntawm cov tshuaj. Tus tsim qauv yuav tsum ua tib zoo xaiv cov qib tsim nyog kom ua tiav cov yam ntxwv tso tawm uas xav tau.
Regulatory xav txog:
HPMC tau txais dav los ua cov tshuaj muaj kev nyab xeeb thiab siv tau zoo. Nws ua tau raws li ntau yam kev cai tswj hwm thiab suav nrog hauv pharmacopoeias thoob ntiaj teb. Cov neeg tsim khoom yuav tsum ua raws li Kev Tswj Xyuas Zoo (GMP) kom ntseeg tau tias qhov zoo thiab sib xws ntawm cov khoom siv tshuaj muaj HPMC.
nyob rau hauv xaus:
Hydroxypropylmethylcellulose (HPMC), raws li ntau yam thiab dav siv excipient, plays lub luag haujlwm tseem ceeb hauv kev lag luam tshuaj. Nws cov khoom tshwj xeeb ua rau nws tsim nyog siv ntau hom tshuaj, suav nrog cov ntsiav tshuaj, tshuaj ntsiav thiab tshuaj kho qhov muag. Formulators tau txais txiaj ntsig los ntawm kev tuaj yeem kho cov khoom ntawm HPMC kom ua tau raws li cov qauv tsim tshwj xeeb, xws li kev tswj hwm kev tso tawm thiab txhim kho kev ruaj ntseg. Txawm hais tias muaj qee qhov kev sib tw, HPMC tseem yog ib qho tseem ceeb hauv kev tsim cov khoom siv tshuaj zoo, ua rau muaj kev nyab xeeb thiab ua tau zoo ntawm ntau hom tshuaj.
Post lub sij hawm: Dec-15-2023