Hydroxypropyl methylcellulose (HPMC) yog cov khoom siv polymer feem ntau siv hauv cov tshuaj, tshuaj pleev ib ce, khoom noj khoom haus, thiab ntau yam kev lag luam. Nws yog siv dav vim nws cov biocompatibility, tsis muaj tshuaj lom, thiab muaj peev xwm hloov kho cov khoom rheological ntawm kev daws teeb meem. Txawm li cas los xij, nws yog ib qho tseem ceeb kom nkag siab tias yuav ua li cas kom tshem tau HPMC kom siv nws cov khoom kom zoo.
Dej: HPMC yog cov dej soluble hauv dej, ua rau nws xaiv rau ntau daim ntawv thov. Txawm li cas los xij, tus nqi ntawm kev sib cais tuaj yeem sib txawv raws li qhov kub thiab txias, pH, thiab qib HPMC siv.
Organic Solvents: Ntau cov kuab tshuaj organic tuaj yeem yaj HPMC rau ntau qhov sib txawv. Qee cov organic solvents muaj xws li:
Cawv: Isopropanol (IPA), ethanol, methanol, thiab lwm yam. Cov cawv no feem ntau siv rau hauv cov tshuaj formulations thiab muaj peev xwm yaj HPMC.
Acetone: Acetone yog cov kuab tshuaj muaj zog uas tuaj yeem yaj HPMC tau zoo.
Ethyl Acetate: Nws yog lwm cov kuab tshuaj organic uas tuaj yeem yaj HPMC zoo.
Chloroform: Chloroform yog ib qho hnyav hnyav dua thiab yuav tsum tau siv nrog ceev faj vim nws toxicity.
Dimethyl Sulfoxide (DMSO): DMSO yog cov kuab tshuaj polar aprotic uas tuaj yeem yaj ntau yam sib txuas, suav nrog HPMC.
Propylene Glycol (PG): PG feem ntau yog siv los ua ib qho kev sib xyaw ua ke hauv cov tshuaj formulations. Nws tuaj yeem yaj HPMC tau zoo thiab feem ntau siv nrog dej lossis lwm cov kuab tshuaj.
Glycerin: Glycerin, tseem hu ua glycerol, yog ib qho hnyav hauv tshuaj thiab tshuaj pleev ib ce. Nws feem ntau yog siv ua ke nrog dej kom yaj HPMC.
Polyethylene Glycol (PEG): PEG yog cov khoom siv polymer nrog cov dej solubility zoo heev hauv dej thiab ntau cov kuab tshuaj organic. Nws tuaj yeem siv los yaj HPMC thiab feem ntau ua haujlwm nyob rau hauv cov qauv tsim tawm.
Surfactants: Qee cov surfactants tuaj yeem pab hauv kev sib cais ntawm HPMC los ntawm kev txo qhov nro thiab txhim kho cov ntub dej. Piv txwv xws li Tween 80, sodium lauryl sulfate (SLS), thiab polysorbate 80.
Strong Acids los yog Bases: Thaum tsis siv ntau vim kev txhawj xeeb txog kev nyab xeeb thiab muaj peev xwm degradation ntawm HPMC, muaj zog acids (piv txwv li, hydrochloric acid) los yog hauv paus (xws li, sodium hydroxide) tuaj yeem yaj HPMC raws li qhov tsim nyog. Txawm li cas los xij, huab cua pH tuaj yeem ua rau degradation ntawm polymer.
Complexing Agents: Qee cov neeg ua haujlwm complexing xws li cyclodextrins tuaj yeem tsim cov complexes nrog HPMC, pab rau nws txoj kev tawg thiab txhim kho nws cov solubility.
Kub: Feem ntau, qhov kub siab dua txhim kho tus nqi ntawm HPMC hauv cov kuab tshuaj zoo li dej. Txawm li cas los xij, qhov kub thiab txias heev tuaj yeem ua rau cov polymer degrade, yog li nws yog qhov tseem ceeb rau kev khiav lag luam hauv qhov kub thiab txias.
Mechanical Agitation: stirring los yog sib tov tuaj yeem pab txhawb kev sib cais ntawm HPMC los ntawm kev ua kom muaj kev sib cuag ntawm cov polymer thiab cov kuab tshuaj.
Particle Loj: Finely hmoov HPMC yuav yaj tau yooj yim dua li cov khoom loj dua vim qhov chaw saum npoo av nce ntxiv.
Nws yog ib qho tseem ceeb uas yuav tsum nco ntsoov tias qhov kev xaiv ntawm cov kuab tshuaj thiab cov kev sib cais yog nyob ntawm daim ntawv thov tshwj xeeb thiab cov khoom xav tau ntawm cov khoom kawg. Kev sib raug zoo nrog lwm cov khoom xyaw, kev xav txog kev nyab xeeb, thiab cov kev cai tswj hwm kuj tseem cuam tshuam rau kev xaiv cov kuab tshuaj thiab cov txheej txheem sib cais. Tsis tas li ntawd, nws yog ib qho tseem ceeb rau kev tshawb fawb txog kev sib raug zoo thiab kev ntsuas kev ruaj ntseg kom ntseeg tau tias cov txheej txheem kev sib cais tsis cuam tshuam rau qhov zoo lossis kev ua tau zoo ntawm cov khoom kawg.
Post lub sij hawm: Mar-22-2024