Hypromellose, tseem hu ua hydroxypropyl methylcellulose (HPMC), yog ib qho khoom siv hluav taws xob semi-synthetic polymer muab los ntawm cellulose. Vim nws cov khoom siv tshuaj lom neeg thiab lub cev tshwj xeeb, HPMC feem ntau yog siv los ua cov thickener, stabilizer thiab nplaum nyob rau hauv kev lag luam tshuaj, zaub mov thiab kev tu tus kheej. Hauv kab lus no, peb tham txog chemistry ntawm HPMCs thiab lawv cov ntawv thov tseem ceeb.
1. Solubility
Ib qho ntawm cov khoom tseem ceeb tshaj plaws ntawm HPMC yog nws cov solubility. HPMC yog soluble hauv dej thiab ntau cov kuab tshuaj organic, ua rau nws yog ib qho khoom siv zoo tagnrho rau kev xa tshuaj thiab lwm yam kev siv uas yuav tsum tau ua kom tawg. Txawm li cas los xij, kev solubility ntawm HPMC feem ntau yog txiav txim siab los ntawm nws qhov kev hloov pauv (DS), uas txiav txim siab tus naj npawb ntawm hydroxypropyl thiab methyl pawg tam sim no hauv cov saw hlau polymer. HPMCs nrog DS siab dua muaj kev solubility qis dua vim muaj kev sib cuam tshuam ntau ntxiv.
2. Rheology
Lwm yam khoom tseem ceeb ntawm HPMC yog nws tus cwj pwm rheological. HPMC lub peev xwm los tsim ib lub gel-zoo li network thaum hydration tuaj yeem siv los tswj cov viscosity thiab ntws cov yam ntxwv ntawm cov qauv. HPMC kuj nthuav tawm tus cwj pwm tsis yog-Newtonian ntws, txhais tau hais tias nws cov viscosity hloov raws li qhov kev thov shear. Cov cuab yeej no tuaj yeem tswj tau ntxiv los ntawm kev kho qhov concentration ntawm HPMC thiab DS hauv kev tsim.
3. Zaj duab xis tsim
HPMC kuj tau siv dav los ua cov yeeb yaj kiab yav dhau los vim tias nws muaj peev xwm tsim cov yeeb yaj kiab tsis zoo thaum siv rau hauv substrate. Cov khoom ua yeeb yaj kiab ntawm HPMC nyob ntawm nws cov DS, viscosity thiab muaj cov yas yas, uas tuaj yeem txhim kho elasticity thiab yooj ntawm cov yeeb yaj kiab. Cov yeeb yaj kiab ua los ntawm HPMC feem ntau yog siv hauv kev xa tshuaj vim tias lawv tso cai tso tawm cov khoom xyaw nquag.
4. Kev sib haum xeeb
HPMC yog ib qho khoom siv tau zoo heev thiab tuaj yeem siv rau ntau hom kev tsim. Nws yog sib xws nrog feem ntau cov khoom xyaw tshuaj, suav nrog cov khoom xyaw tshuaj nquag (APIs) thiab lwm yam khoom siv uas nquag siv hauv cov tshuaj formulations. HPMC kuj tseem sib xws nrog ntau cov khoom xyaw zaub mov, ua rau nws yog qhov kev xaiv nrov rau kev siv zaub mov.
5. Tshuaj stability
HPMC yog ib qho ruaj khov polymer uas tiv thaiv hydrolysis thiab lwm yam tshuaj tiv thaiv. Qhov kev ruaj ntseg no ua rau nws muaj qhov zoo tshaj plaws rau kev xa tshuaj raws li nws tiv thaiv cov khoom muaj txiaj ntsig los ntawm kev degradation thiab nce nws cov bioavailability. Txawm li cas los xij, cov tshuaj lom neeg ruaj khov ntawm HPMC tuaj yeem cuam tshuam los ntawm qhov kub thiab txias, cov av noo, thiab qee cov kuab tshuaj, uas tuaj yeem ua rau cov polymer degrade thiab txo nws cov txiaj ntsig hauv formulations.
6. Biocompatibility
Thaum kawg, HPMC yog cov khoom siv biocompatible polymer uas muaj kev nyab xeeb rau kev siv tshuaj thiab cov khoom tu tus kheej. Nws yog non-toxic, non-immunogenic thiab biodegradable, ua rau nws zoo tagnrho rau formulations uas yuav tsum tau tsawg kawg nkaus toxicity thiab siab tshaj plaws kev nyab xeeb.
Nyob rau hauv cov ntsiab lus, HPMC hypromellose yog ib tug multifunctional polymer nrog ntau yam ntawm cov tshuaj tseem ceeb, xws li solubility, rheology, film-forming zog, compatibility, tshuaj stability, thiab biocompatibility. Cov khoom no ua rau nws yog qhov zoo tshaj plaws rau kev xa tshuaj thiab lwm yam kev siv hauv kev lag luam zaub mov thiab kev saib xyuas tus kheej. Raws li kev tshawb fawb txuas ntxiv nthuav peb txoj kev nkag siab ntawm HPMCs, lawv cov khoom tshwj xeeb yuav pom cov ntawv thov dav dua yav tom ntej.
Post lub sij hawm: Lub Xya hli ntuj-28-2023