HydroxyPropyyl Methylcellulose (HPMC) Yog ib txwm siv polymer compound, siv dav siv hauv kev tsim kho, chaw muag tshuaj, zaub mov thiab lwm yam lag luam. Raws li cov dej-soluble polymer, HPMC muaj dej zoo heev, ua yeeb yaj kiab ua yeeb yaj kiab, thickening thiab emulsifying thiab emulsifying thiab emulsifying thiab emulsifying thiab emulsifying thiab emulsifying thiab emulsifying thiab emulsifying thiab emulsifying thiab emulsifying thiab emulsifying thiab emulsifying thiab emulsifying thiab emulsifying thiab emulsifying thiab emulsifying thiab emulsifying thiab emulsifying thiab emulsifying thiab emulsifying thiab emulsifying thiab emulsifying thiab emulsifying thiab emulsifying thiab emulsifying thiab emulsifying cov zog. Nws cov dej khaws cia yog ib qho ntawm nws cov peev txheej tseem ceeb hauv ntau cov ntawv thov, uas tuaj yeem ncua kev tsim kho dej thiab txhim kho kev ua haujlwm zoo thiab kev ua tau zoo ntawm cov khoom kawg. Txawm li cas los xij, cov dej khaws cia ntawm HPMC yog ze ze rau qhov ntsuas kub nyob rau hauv ib puag ncig sab nraud, thiab to taub cov kev sib raug zoo no yog qhov tseem ceeb rau nws cov ntawv thov.
1. Cov qauv thiab cov dej khaws cia HPMC
HPMC yog tsim los ntawm cov tshuaj kho mob ntawm ntuj cellulose, feem ntau yog los ntawm kev qhia ntawm hydroxypropyl (-ch3) pab pawg rau hauv lub cellulose saw, uas muab nws zoo solubility thiab cov teeb meem kev cai. Cov pab pawg hydroxyl (-h) nyob rau hauv HPMC lwg me me tuaj yeem tsim cov hydrogen bonds nrog dej lwg me me. Yog li ntawd, HPMC tuaj yeem nqus dej thiab sib txuas nrog dej, ua kom dej ua kom rov ua haujlwm.
Dej khaws cia yog hais txog qhov muaj peev xwm ntawm cov tshuaj kom tuav dej. Rau HPMC, nws yog feem ntau yog ua kom nws muaj peev xwm tswj cov ntsiab lus dej hauv cov kab ke, uas tuaj yeem tiv thaiv cov dej kub sai thiab ua kom cov wettability ntawm cov tshuaj. Txij li thaum co dej hauv HPMC lwg me me cuam tshuam nrog kev sib cuam tshuam ntawm cov qauv molecular yuav cuam tshuam ncaj qha rau cov dej muaj peev xwm thiab dej khaws cia HPMC.
2. Cov nyhuv ntawm cov dej khaws cia ntawm HPMC
Kev sib raug zoo ntawm cov dej khaws cia ntawm HPMC thiab qhov kub thiab txias tuaj yeem sib tham los ntawm ob qho kev kub ntxhov ntawm HPMC, thiab lwm yam yog qhov cuam tshuam ntawm nws cov qauv molecular thiab cov dej.
2.1 nyhuv ntawm qhov kub ntawm solubility ntawm HPMC
Lub solubility ntawm HPMC hauv dej cuam tshuam nrog kub. Feem ntau, cov solubility ntawm HPMC nce nrog kev nce kub. Thaum kub nce, dej molecules tau ntau lub zog thermal, uas ua rau muaj zog ntawm kev sib cuam tshuam ntawm cov dej lwg me me, yog li txhawb kev sib cais ntawm HPMCCov. Rau HPMC, qhov nce nyob rau hauv qhov kub yuav ua rau nws yooj yim dua los tsim cov tshuaj colloidal, yog li txhim kho nws cov dej khaws cia hauv dej.
Txawm li cas los xij, kev kub dhau heev yuav ua rau muaj visco ntawm HPMC, cuam tshuam rau nws cov khoom siv hluav taws xob thiab kev tsis txaus ntseeg. Txawm hais tias cov nyhuv no yog qhov zoo rau kev txhim kho ntawm solubility, kub siab yuav hloov pauv qhov ruaj khov ntawm nws cov qauv molecular thiab ua rau txo qis hauv dej rov qab.
2.2 cov nyhuv ntawm qhov kub ntawm cov qauv molecular ntawm HPMC
Nyob rau hauv cov qauv molecular ntawm HPMC, Hydrogen Bonds feem ntau yog tsim nrog cov roj av molecules los ntawm pawg hydroxyl, thiab cov pab pawg hydroxeny yog qhov tseem ceeb rau HOLMC. Raws li qhov kub nce ntxiv, lub zog ntawm hydrogen bond yuav hloov pauv, ua rau muaj qhov tsis muaj zog ntawm HPMC lwg thiab cuam tshuam rau nws cov dej khaws cia. Tshwj xeeb, qhov nce nyob rau hauv kub yuav ua rau cov hydrogen bonds nyob rau hauv Hydrogen Bads hauv Helmc molecule kom tshem tawm nws cov dej nqus thiab dej returent muaj peev xwm.
Tsis tas li ntawd, qhov ntsuas kub rhiab ntawm HPMC kuj tseem cuam tshuam hauv theem tus cwj pwm ntawm nws txoj kev daws teeb meem. HPMC nrog cov hnyav molecular thiab cov pab pawg hloov sib txawv muaj cov sib txawv thermal conensitivities. Feem ntau hais lus, qis molecular hnyav HPMC yog ntau rhiab rau qhov kub, thaum lub siab molecular hnyav HPMC cov khoom pov thawj ua tau zoo dua. Yog li ntawd, hauv kev siv cov ntawv thov, nws yog qhov tsim nyog los xaiv HPMC tsim nyog raws li qhov ntsuas kub tshwj xeeb kom ntseeg tau tias nws cov dej khaws cia ntawm kev ua haujlwm kub.
2.3 Cov nyhuv ntawm qhov kub ntawm cov dej evaporation
Nyob rau hauv cov kev kub ntxhov siab, dej tuav HPM yuav cuam tshuam los ntawm dej evaporation los ntawm kev nce hauv qhov kub kom nce ntxiv. Thaum qhov kub sab nraud dhau lawm, cov dej hauv HPMC system muaj feem ntau yuav yaj. Txawm hais tias HPMC tuaj yeem khaws cov dej mus rau qee yam los ntawm nws cov qauv molecular, cov kub siab dhau yuav ua rau lub zog poob nrawm dua li lub peev xwm dej ceev ceev ntawm HPMC. Hauv qhov no, cov dej tuav tseg ntawm HPMC yog inhibited, tshwj xeeb tshaj yog nyob rau hauv qhov kub thiab qhuav ib puag ncig.
Txhawm rau txo cov teeb meem no, qee cov kev tshawb fawb tau pom tias ntxiv cov khoom siv kom tsim nyog lossis kho kom zoo dua ntawm HPMC hauv kev kub siab ib puag ncig. Piv txwv li, los ntawm kev kho lub viscosity hloov pauv hauv cov mis lossis xaiv cov dej khov ntawm HPMC tuaj yeem txhim kho kom tau ib qho ntxiv, txo cov nyhuv ntawm cov dej ntws evap.
3. Txom Nyem Cov Lus Qhia
Cov nyhuv ntawm cov dej tuav tseg ntawm HPMC nyob ntawm tsis yog tsuas yog nyob rau ntawm qhov hnyav, tab sis kuj yog hloov chaw, kev daws teeb meem thiab lwm yam ntawm HPMC. Piv txwv li:
Molecular hnyav:HPMC Nrog lub cev hnyav dua feem ntau muaj cov qauv kev ua kom muaj zog ua kom tiav los ntawm cov tshuaj migh molecular hnyav tau tsim los ntawm cov tshuaj muaj peev xwm nqus tau thiab khaws dej kom tau zoo dua.
Degree ntawm hloov methylation thiab hydroxypropation ntawm HOLMC yuav cuam tshuam nws cov kev sib cuam tshuam nrog dej lwg me, yog li cuam tshuam dej khaws cia. Feem ntau hais lus, qib siab dua ntawm kev hloov pauv tuaj yeem txhim kho Hydrophilicity ntawm Hydrophilicity ntawm Hydrophilicity ntawm Hydrophilicity ntawm Hydmc, li kev txhim kho nws cov dej khaws cia.
Kev daws teeb meem: kev xav ntawm HPMC tseem cuam tshuam nws cov dej khaws cia. Cov kev daws teeb meem ntau dua ntawm HPMC cov kev daws teeb meem feem ntau muaj cov dej ua kom zoo dua qub
Muaj ib txoj kev sib raug zoo ntawm cov dej rov qab los ntawmHPMCthiab kub. Muaj zog ntau ntxiv txhawb nqa cov solubility ntawm HPMC thiab tej zaum yuav rhuav tshem cov qauv molcc, txo qis nws lub peev xwm los khi rau dej, thiab yog li cuam tshuam nws cov dej ua kom ruaj khov. Txhawm rau kom ua tiav cov dej ua kom zoo tshaj plaws nyob rau hauv ntau yam kub thiab yog qhov tsim nyog los xaiv cov kev thov HPMC uas tsim nyog raws li kev xav tau thiab kho tau nws siv. Ib qho ntxiv, lwm yam hauv cov qauv thiab ntsuas kub tswj tau los kuj tseem tuaj yeem txhim kho cov dej tuav tseg ntawm HPMC hauv qhov chaw kub nyob ib puag ncig.
Lub Sijhawm Post: Nov-11-2024