Tsawg-substituted hydroxypropyl cellulose (L-HPC) yog ib tug derivative ntawm cellulose, ib tug natural polymer pom nyob rau hauv cov nroj tsuag cell phab ntsa. L-HPC tau raug hloov kho los txhim kho nws cov solubility thiab lwm yam khoom, ua rau nws muaj ntau yam khoom siv nrog ntau yam kev siv hauv kev lag luam tshuaj, zaub mov, thiab tshuaj pleev ib ce.
Tsawg-substituted hydroxypropylcellulose (L-HPC) yog ib qho qis-siv cellulose derivative uas tau hloov kho feem ntau los txhim kho nws cov solubility hauv dej thiab lwm cov kuab tshuaj. Cellulose yog ib tug linear polysaccharide tsim los ntawm cov piam thaj units uas muaj ntau nyob rau hauv cov xwm thiab yog ib feem ntawm cov nroj tsuag cell phab ntsa. L-HPC yog synthesized los ntawm chemically modifying cellulose, qhia hydroxypropyl pawg los txhim kho nws solubility thaum tuav ib co ntawm cov khoom uas xav tau ntawm cellulose.
Cov qauv tshuaj ntawm cov uas tsis tshua muaj kev hloov pauv hydroxypropyl cellulose
Cov qauv tshuaj ntawm L-HPC muaj cov pob txha cellulose thiab ib pawg hydroxypropyl txuas nrog hydroxyl (OH) pawg ntawm cov piam thaj. Qhov degree ntawm kev hloov pauv (DS) yog hais txog qhov nruab nrab ntawm cov pawg hydroxypropyl ib chav tsev piam thaj hauv cov saw cellulose. Hauv L-HPC, DS yog txhob txwm cia qis kom sib npaug txhim kho kev solubility nrog kev tswj xyuas cov khoom ntawm cov cellulose.
Synthesis ntawm low-substituted hydroxypropyl cellulose
Lub synthesis ntawm L-HPC cuam tshuam cov tshuaj tiv thaiv ntawm cellulose nrog propylene oxide nyob rau hauv lub xub ntiag ntawm ib tug alkaline catalyst. Cov tshuaj tiv thaiv no ua rau kev taw qhia ntawm pawg hydroxypropyl mus rau hauv cov saw cellulose. Kev tswj xyuas zoo ntawm cov tshuaj tiv thaiv, suav nrog qhov kub thiab txias, lub sijhawm tshuaj tiv thaiv, thiab catalyst concentration, yog qhov tseem ceeb kom ua tiav qhov kev xav tau ntawm kev hloov pauv.
Yam cuam tshuam rau solubility
1. Degree ntawm kev hloov pauv (DS):
Lub solubility ntawm L-HPC cuam tshuam los ntawm nws cov DS. Raws li DS nce, qhov hydrophilicity ntawm pawg hydroxypropyl ua tau zoo dua, yog li kev txhim kho solubility hauv dej thiab polar solvents.
2. Molecular Luj:
Qhov hnyav molecular ntawm L-HPC yog lwm qhov tseem ceeb. L-HPC ntau dua molecular hnyav tuaj yeem ua rau txo qis solubility vim muaj kev sib cuam tshuam ntau ntxiv thiab kev sib txuas ntawm cov saw hlau.
3. Kub:
Solubility feem ntau nce nrog qhov kub thiab txias vim tias qhov kub siab dua muab lub zog ntau dua los rhuav tshem cov rog hauv nruab nrab thiab txhawb kev sib cuam tshuam ntawm polymer-solvent.
4. pH tus nqi ntawm kev daws:
Cov pH ntawm cov tshuaj cuam tshuam rau ionization ntawm hydroxypropyl pawg. Qee zaum, kho cov pH yuav ua rau kom cov solubility ntawm L-HPC.
5. Hom kuab tshuaj:
L-HPC nthuav tawm zoo solubility hauv dej thiab ntau yam polar solvents. Kev xaiv cov kuab tshuaj yog nyob ntawm daim ntawv thov tshwj xeeb thiab cov khoom xav tau ntawm cov khoom kawg.
Daim ntawv thov ntawm qis hloov hydroxypropyl cellulose
1. Tshuaj:
L-HPC yog dav siv nyob rau hauv kev lag luam kws tshuaj raws li ib tug binder, disintegrant thiab tswj tso tawm tus neeg sawv cev nyob rau hauv cov ntsiav tshuaj formulations. Nws solubility nyob rau hauv gastrointestinal kua ua rau nws haum rau kev siv tshuaj xa.
2. Khoom noj khoom haus kev lag luam:
Hauv kev lag luam zaub mov, L-HPC yog siv los ua cov thickener thiab stabilizer hauv ntau yam khoom. Nws lub peev xwm los tsim cov gel ntshiab yam tsis muaj kev cuam tshuam rau saj lossis xim ntawm cov khoom noj khoom haus ua rau nws muaj txiaj ntsig hauv kev tsim khoom noj.
3. Tshuaj pleev ib ce:
L-HPC yog siv rau hauv cov tshuaj pleev ib ce rau nws cov yeeb yaj kiab-tsim thiab thickening zog. Nws pab txhim kho kev ruaj ntseg thiab kev ntxhib los mos ntawm cov tshuaj pleev ib ce xws li cream, lotions thiab gels.
4. Daim ntawv thov txheej:
L-HPC tuaj yeem siv los ua cov khoom siv zaj duab xis txheej hauv kev lag luam tshuaj thiab zaub mov los muab cov txheej txheem tiv thaiv rau cov ntsiav tshuaj lossis cov khoom noj khoom haus.
Tsawg-substituted hydroxypropyl cellulose yog ib tug multifunctional polymer nrog txhim kho solubility muab tau los ntawm ntuj cellulose pom nyob rau hauv cov nroj tsuag. Nws cov khoom tshwj xeeb ua rau nws muaj txiaj ntsig hauv ntau yam kev lag luam xws li tshuaj, khoom noj thiab tshuaj pleev ib ce. Kev nkag siab txog yam uas cuam tshuam rau nws cov solubility yog qhov tseem ceeb rau kev ua kom zoo dua nws siv hauv ntau daim ntawv thov. Raws li kev tshawb fawb txog kev tshawb fawb thiab kev tsim kho polymer txuas ntxiv mus, L-HPC thiab cov khoom siv cellulose zoo sib xws tuaj yeem pom cov ntawv thov tshiab thiab tshiab hauv ntau thaj chaw.
Post lub sij hawm: Dec-26-2023