Hydroxypropylmethylcellulose (HPMC), raws li ib tug nquag siv hydrophilic polymer nyob rau hauv kev lag luam kws tshuaj, yog dav siv nyob rau hauv cov ntsiav tshuaj coatings, tswj kev tso tawm formulations thiab lwm yam tshuaj xa systems. Ib qho ntawm cov khoom tseem ceeb ntawm HPMC yog nws lub peev xwm khaws cov dej, uas cuam tshuam rau nws qhov kev ua tau zoo raws li cov khoom siv tshuaj. Hauv tsab xov xwm no, peb yuav tshawb txog cov ntsiab lus tseem ceeb cuam tshuam rau kev tuav dej ntawm HPMC, suav nrog qhov hnyav molecular, hloov hom, concentration, thiab pH.
molecular hnyav
Qhov hnyav molecular ntawm HPMC ua lub luag haujlwm tseem ceeb hauv kev txiav txim siab nws lub peev xwm tuav dej. Feem ntau, qhov hnyav molecular HPMC yog hydrophilic ntau dua li qhov hnyav molecular HPMC thiab tuaj yeem nqus dej ntau dua. Qhov no yog vim qhov hnyav dua molecular HPMCs muaj cov saw ntev ntev uas tuaj yeem cuam tshuam thiab tsim kom muaj kev sib txuas ntau dua, ua kom cov dej tuaj yeem nqus tau. Txawm li cas los xij, nws yuav tsum tau muab sau tseg tias HPMC hnyav molecular hnyav heev yuav ua rau muaj teeb meem xws li viscosity thiab kev ua haujlwm nyuaj.
lwm txoj
Lwm qhov tseem ceeb uas cuam tshuam txog kev tuav dej ntawm HPMC yog hom kev hloov pauv. HPMC feem ntau tuaj nyob rau hauv ob hom: hydroxypropyl-hloov thiab methoxy-hloov. Hom hydroxypropyl-substituted muaj peev xwm nqus dej ntau dua li hom methoxy-substituted. Qhov no yog vim hais tias pawg hydroxypropyl tam sim no nyob rau hauv HPMC molecule yog hydrophilic thiab ua rau kom muaj kev sib raug zoo ntawm HPMC rau dej. Nyob rau hauv sib piv, hom methoxy-hloov hom yog tsawg hydrophilic thiab yog li ntawd muaj ib tug qis dej tuav peev xwm. Yog li, lwm hom HPMC yuav tsum tau ua tib zoo xaiv raws li qhov xav tau ntawm cov khoom kawg.
tsom ntsoov rau
Qhov concentration ntawm HPMC kuj cuam tshuam rau nws lub peev xwm tuav dej. Ntawm qhov tsis tshua muaj siab, HPMC tsis tsim cov qauv zoo li gel, yog li nws cov dej tuav tau tsawg. Raws li qhov concentration ntawm HPMC nce, cov polymer molecules pib entangle, tsim ib tug gel zoo li qauv. Cov gel network no absorbs thiab khaws cov dej, thiab cov dej tuav lub peev xwm ntawm HPMC nce nrog concentration. Txawm li cas los xij, nws yuav tsum raug sau tseg tias qhov siab ntawm HPMC ntau dhau yuav ua rau muaj teeb meem kev tsim xws li viscosity thiab kev ua haujlwm nyuaj. Yog li, qhov concentration ntawm HPMC siv yuav tsum tau ua kom zoo kom ua tiav cov dej uas xav tau khaws cia thaum zam cov teeb meem uas tau hais los saum toj no.
Tus nqi PH
Tus nqi pH ntawm ib puag ncig uas HPMC siv kuj yuav cuam tshuam rau nws lub peev xwm tuav dej. Cov qauv HPMC muaj anionic pawg (-COO-) thiab pawg hydrophilic ethylcellulose (-OH). Cov ionization ntawm -COO- pab pawg yog pH nyob ntawm, thiab lawv cov qib ionization nce nrog pH. Yog li, HPMC muaj peev xwm khaws dej ntau dua ntawm pH siab. Thaum qis pH, -COO- pab pawg yog protonated thiab nws cov hydrophilicity txo qis, ua rau muaj peev xwm khaws dej tsawg. Yog li ntawd, ib puag ncig pH yuav tsum tau ua kom zoo kom ua tiav cov dej khaws cia ntawm HPMC.
nyob rau hauv xaus
Hauv kev xaus, lub peev xwm khaws dej ntawm HPMC yog qhov tseem ceeb cuam tshuam rau nws qhov kev ua tau zoo raws li cov khoom siv tshuaj. Cov yam tseem ceeb uas cuam tshuam rau kev tuav dej ntawm HPMC muaj xws li qhov hnyav molecular, hloov hom, concentration thiab pH tus nqi. Los ntawm kev ua tib zoo kho cov xwm txheej no, lub peev xwm khaws dej ntawm HPMC tuaj yeem ua kom zoo kom ua tiav cov khoom xav tau ntawm cov khoom kawg. Cov kws tshawb fawb tshuaj thiab cov tuam txhab lag luam yuav tsum tau ua tib zoo saib xyuas cov xwm txheej no kom ntseeg tau tias qhov zoo tshaj plaws thiab kev ua tau zoo ntawm HPMC-based tshuaj formulations.
Post lub sij hawm: Aug-05-2023