Hydroxypropyl methylcellulose (HPMC) yog ntau yam polymer nrog ob qho tib si hydrophobic thiab hydrophilic zog, ua rau nws tshwj xeeb hauv ntau daim ntawv thov thoob plaws kev lag luam sib txawv. Txhawm rau kom nkag siab txog hydrophobicity thiab hydrophilicity ntawm HPMC, peb yuav tsum kawm nws cov qauv, cov khoom thiab kev siv hauv qhov tob.
Cov qauv ntawm hydroxypropyl methylcellulose:
HPMC yog ib qho derivative ntawm cellulose, ib tug natural polymer pom nyob rau hauv cov nroj tsuag cell phab ntsa. Kev hloov pauv ntawm cellulose suav nrog kev qhia txog hydroxypropyl thiab methyl pawg rau hauv cov pob txha cellulose. Qhov kev hloov kho no hloov cov khoom ntawm cov polymer, muab cov khoom tshwj xeeb uas muaj txiaj ntsig zoo rau ntau yam kev siv.
Hydrophilicity ntawm HPMC:
Hydroxy:
HPMC muaj cov pab pawg hydroxypropyl thiab yog hydrophilic. Cov pab pawg hydroxyl no muaj kev sib raug zoo rau cov dej molecules vim hydrogen bonding.
Hydroxypropyl pawg tuaj yeem tsim hydrogen bonds nrog dej molecules, ua HPMC soluble hauv dej rau qee yam.
methyl:
Thaum cov methyl pawg pab txhawb rau tag nrho cov hydrophobicity ntawm cov molecule, nws tsis counteract hydrophilicity ntawm pawg hydroxypropyl.
Cov pab pawg methyl yog qhov tsis yog-polar, tab sis muaj cov pab pawg hydroxypropyl txiav txim siab tus cwj pwm hydrophilic.
Hydrophobicity ntawm HPMC:
methyl:
Cov pab pawg methyl hauv HPMC txiav txim siab rau qee qhov nws cov hydrophobicity.
Txawm hais tias tsis yog hydrophobic li qee cov khoom siv hluavtaws tag nrho, qhov muaj cov methyl pawg txo cov hydrophilicity tag nrho ntawm HPMC.
Film forming zog:
HPMC paub txog nws cov khoom ua yeeb yaj kiab thiab feem ntau siv hauv kev siv tshuaj thiab tshuaj pleev ib ce. Hydrophobicity pab txhawb kev tsim cov yeeb yaj kiab tiv thaiv.
Kev sib cuam tshuam nrog cov khoom tsis muaj polar:
Hauv qee daim ntawv thov, HPMC tuaj yeem cuam tshuam nrog cov khoom tsis yog polar vim nws cov hydrophobicity ib nrab. Cov cuab yeej no yog qhov tseem ceeb rau kev xa cov tshuaj hauv kev lag luam kws tshuaj.
Kev siv ntawm HPMC:
tshuaj:
HPMC yog dav siv nyob rau hauv cov tshuaj formulations raws li ib tug binder, zaj duab xis qub, thiab viscosity modifier. Nws lub peev xwm ua yeeb yaj kiab ua kom yooj yim tswj kev tso tshuaj.
Nws yog siv nyob rau hauv qhov ncauj khoom noj cov ntaub ntawv xws li ntsiav tshuaj thiab tsiav tshuaj.
Kev tsim kho kev lag luam:
Hauv kev tsim kho, HPMC yog siv hauv cov khoom siv cement los txhim kho kev ua haujlwm, dej tuav thiab adhesion.
Hydrophilicity pab khaws dej, thaum hydrophobicity pab txhim kho adhesion.
kev lag luam zaub mov:
HPMC yog siv los ua cov thickener thiab gelling tus neeg sawv cev hauv kev lag luam khoom noj. Nws qhov xwm txheej hydrophilic pab tsim cov gels ruaj khov thiab tswj cov viscosity ntawm cov khoom noj.
tshuaj pleev ib ce:
Nyob rau hauv cov tshuaj pleev ib ce, HPMC yog siv nyob rau hauv cov khoom xws li cream thiab tshuaj pleev ib ce vim nws cov zaj duab xis-forming thiab thickening zog.
Hydrophilicity xyuas kom zoo hydration ntawm daim tawv nqaij.
nyob rau hauv xaus:
HPMC yog ib qho polymer uas yog hydrophilic thiab hydrophobic. Qhov sib npaug ntawm hydroxypropyl thiab methyl pawg hauv nws cov qauv muab nws qhov tshwj xeeb versatility, tso cai rau nws muaj ntau yam kev siv. Kev nkag siab txog cov khoom no yog qhov tseem ceeb rau kev txiav HPMC rau kev siv tshwj xeeb hauv kev lag luam sib txawv, qhov twg lub peev xwm ntawm HPMC cuam tshuam nrog cov dej thiab cov khoom tsis muaj polar yog siv rau ntau lub hom phiaj.
Post lub sij hawm: Dec-15-2023