1. Qhov pib ntawm HPMC
Hypromellose, English npe hydroxypropyl methylulose, alias HPMC. Nws cov roj molecular yog c8h15o8- (c10hl8o6) n-c8hl5o8, thiab molecular hnyav yog hais txog 86,000. Cov khoom no yog cov khoom siv hluavtaws ib nrab, uas yog ib feem ntawm cov methyl pawg thiab ib feem ntawm polyhydrop etherroploplo. Nws tuaj yeem tsim los ntawm ob txoj kev: Ib qho yog kho cov methyl cellulose ntawm qib tsim nyog nrog propylene oxide hauv qab kub thiab siab siab. Lub sijhawm kev tawm tsam yuav tsum tau txhawb nqa kom tso cai rau methyl thiab hydroxypropropyl pab nyiaj nrog ether. Daim ntawv ntawm tau txuas nrog lub anhydoglulucose nplhaib ntawm cellulose, thiab tuaj yeem ncav cuag cov qib xav tau; Lwm tus yog kho cov paj rwb lam ci lossis ntoo pulp fiber ntau nrog cov tshuaj me, thiab tom qab ntawd tau txais txiaj ntsig zoo, thiab tom qab ntawd ua kom zoo nkauj, ua rau kom zoo thiab hnav khaub ncaws hnav zoo. HPMC yog ntau yam ntawm ntuj cog cellulose, thiab nws kuj yog ib qho kev zam zoo tshaj plaws, uas muaj qhov dav dav. Nyob rau tam sim no, nws yog dav siv nyob hauv tsev thiab txawv teb chaws, thiab nws yog ib qho ntawm cov tshuaj uas muaj kev cia siab nrog kev siv tshuaj ntau tshaj plaws ntawm cov tshuaj.
Cov xim ntawm cov khoom no yog xim dawb rau milky dawb, tsis muaj tshuaj lom thiab qab, thiab nws yog cov hmoov av zoo lossis ua kom tau zoo. Nws yog qhov ruaj khov nyob rau hauv lub teeb kis lub teeb thiab cov av noo. Nws swells nyob rau hauv dej txias los ua ib lub milky dawb colloidal tov nrog qee qhov degree ntawm viscosity. Lub sol-gel interconversion qhov tshwm sim tuaj yeem tshwm sim vim qhov ntsuas kub hloov ntawm qee qhov kev xav ntawm kev daws teeb meem. Nws yog qhov yooj yim heev rau yaj hauv 70% dej cawv los yog dimethyl ketone, thiab yuav tsis yaj nyob rau hauv dej cawv uas tsis muaj dab tsi, chloroform lossis urneloform lossis urnoHYethane.
Hypromellose muaj kev ruaj khov zoo thaum lub p p yog nruab nrab ntawm 4.0 thiab nws tuaj yeem muaj nyob ntawm 3.0 thiab 11.0. Tom qab khaws cia rau 10 hnub ntawm qhov kub ntawm 20 ° C thiab ib tug txheeb ze cov av noo ntawm 80%, noo noo nqus coefficient ntawm HPMC yog 6.2%.
Vim qhov txawv nyob rau hauv cov ntsiab lus ntawm ob qho kev hloov pauv ntawm hypromellose, methoxy thiab hydroxypropyl, ntau hom khoom tau tshwm sim. Hauv qhov tshwj xeeb tshaj plaws, ntau hom khoom muaj cov viscosity thiab thermal gelation kub, yog li ntawd, muaj cov khoom sib txawv thiab tuaj yeem siv rau cov laj thawj sib txawv. Lub Pharmacopoeias ntawm ntau lub tebchaws muaj cov kev sib txawv thiab cov lus qhia rau tus qauv: European cov chaw nres tsheb nyob sab Europe thiab cov qib sib txawv ntawm cov khoom lag luam ntawm kev ua lag luam. Nws tau qhia los ntawm tus lej ntxiv rau tus lej. Chav tsev yog MPA • s. Tom qab ntxiv 4 tus lej los qhia cov ntsiab lus thiab hom ntawm txhua tus lej ntawm cov methoxy pab pawg, ob tus lej thib kawg sawv cev rau hydroxyprropal feem pua ntawm cov neeg mob.
2.Qhov txoj kev ntawm cov lus HPMC hauv dej
2.1 Cov Dej Dej Kub
Txij li thaum hypromellose tsis yaj hauv dej kub, nws tuaj yeem sib xyaw ua ke hauv dej kub ntawm theem pib, thiab tom qab ntawd thaum nws txias, ob txoj kev tau piav qhia raws li nram no:
(1) Muab cov dej kub uas yuav tsum muaj dej kub hauv lub thawv thiab cua sov nws txog 70 ℃. Maj mam ntxiv cov khoom hauv qeeb qeeb. Thaum pib, cov khoom ntab nyob rau saum npoo ntawm dej, thiab tom qab ntawd maj mam ua ib tug slurry. Txias cia cov slurry.
(2) Ntxiv rau 1/3 lossis 2/3 ntawm qhov yuav tsum tau dej rau hauv lub thawv thiab cua sov kom npaj cov dej txias lossis dej khov Mus rau cov dej kub hauv dej hauv lub slurry, txias sib tov tom qab nplawm.
2.2 Hmoov sib xyaw txuj
Cov hmoov nplej thiab lwm cov khoom xyaw ntawm vaj huam sib luag lossis cov nyiaj ntau dua tau tawg los ntawm kev sib xyaw qhuav, thiab tom qab ntawd dej ntxiv rau yaj. Nyob rau lub sijhawm no, lub hypromellose tuaj yeem yaj tsis muaj agglomeration.
3. Qhov zoo ntawm HPMC
3.1 Lub cev dej txias
Nws yog soluble hauv dej txias dua 40 ° C lossis 70% ethanol. Nws yog qhov tseem insoluble hauv dej kub saum toj kawg li 60 ° C, tab sis nws tuaj yeem yog gelled.
3.2 Tshuaj lom neeg inertness
Hypromellose (HPMC) yog hom ntawm cov tsis muaj ionic cellulose ether. Nws cov kev daws teeb meem tsis muaj ionic them thiab tsis cuam tshuam nrog cov kav hlau hlau lossis ionic organic sib txuas. Yog li ntawd, lwm yam kev zam tsis yog kev tawm tsam nrog nws thaum lub sijhawm npaj.
3.3 Txom Nyem
Nws yog qhov sib luag rau ob qho tib si qaub thiab alkali, thiab tuaj yeem khaws cia ntev li ntawm PH 3 txog 1L, thiab nws cov viscosity tsis muaj kev hloov pauv. Cov tshuaj aqueous ntawm hypromellose (HPMC) muaj kev tawm tsam pwm thiab tuaj yeem tswj cov viscosity zoo thaum lub sijhawm ntev cia. Cov tshuaj uas tau siv tshuaj siv HPMC muaj cov khoom ruaj khov zoo dua li cov uas siv cov khoom siv tshuaj lom neeg (xws li Dextrin, cov hmoov txhuv nplej siab, thiab lwm yam).
3.4 Kev kho tau ntawm viscosity
Qhov txawv viscosity ntawm HPMC tuaj yeem sib xyaw nrog cov cai sib txawv, thiab nws txoj cai lij choj zoo, yog li nws tuaj yeem xaiv raws li qhov yuav tsum tau ua.
3.5 metabolic inertia
HPMC tsis tau nqus lossis metabolized hauv lub cev, thiab tsis muab calories, yog li nws yog kev nyab xeeb rau kev npaj tshuaj.
3.6 kev ruaj ntseg
Nws yog feem ntau ntseeg tias HPMC yog cov tsis muaj tshuaj lom thiab tsis yog cov khoom siv tsis zoo. Lub nruab nrab ntawm lub cev ua kom tuag rau cov nas yog 5g / kg, thiab lub nruab nrab ntawm ib qho koob tshuaj kom tuag rau nas yog 5.2g / kg. Cov tshuaj txhua hnub yog tsis muaj mob rau tib neeg lub cev.
4. Daim ntawv thov ntawm HPMC hauv kev npaj
4.1 siv ua zaj duab xis txheej khoom thiab zaj duab xis ruaj ruaj khoom
Hypromellose (HPMC) yog siv los ua zaj duab xis-coated ntsiav tshuaj khoom. Piv nrog cov ntsiav tshuaj ib txwm muaj xws li cov ntsiav tshuaj muaj suab thaj, cov xim sib zog, tab sis lawv cov ntsuas qhov hnyav thiab lwm yam khoom siv tau zoo dua. Qeb qis-viscosity ntawm cov khoom lag luam-doluble zaj duab xis yog siv raws li cov khoom siv ua yeeb yaj kiab rau cov txheej txheem organic. Kev siv kev xav tau yog feem ntau 2.0% -20%.
4.2 ua cov binder thiab ua txhaum cai
Qhov qis-viscosity qib ntawm cov khoom lag luam no tuaj yeem siv los ua cov phau ntawv, ntsiav tshuaj, thiab cov granule, thiab cov grancosity qib tsuas yog siv los ua phau ntawv. Cov tshuaj yaug sib txawv nrog cov qauv sib txawv thiab cov cai. Feem ntau, tus nqi ntawm phau ntawv siv rau cov ntsiav tshuaj granulation qhuav yog 5%, thiab tus nqi ntawm phau ntawv siv rau cov ntsiav tshuaj av granulation ntub yog 2%.
4.3 raws li tus neeg sawv cev ncua
Cov neeg sawv cev ncua kev ncua yog lub hom phiaj ua kua pleev nrog hydrophilicity. Kev siv cov neeg sawv cev ncua kev ncua uas tsis tau txais cov neeg sawv cev qeeb, thiab nws tuaj yeem txuas nrog cov hais tawm los ntawm polymerizing thiab condensing rau hauv ib qho loj. Cov neeg sawv cev ncua kev ncua ntawv ua si ib lub luag haujlwm tseem ceeb hauv kev tsim cov kev ncua. HPMC yog ib qho zoo tshaj plaws ntawm cov neeg sawv cev tsis raug. Lub colloidal tov yaj mus rau nws tuaj yeem txo cov nro ntawm cov kua-interface part, yog li txhim kho qhov ruaj khov ntawm cov heterogeneous system. Cov khoom no yog lub siab-viscosity excomple npaj npaj tus neeg sawv cev. Nws muaj cov txiaj ntsig zoo tau ncua, yooj yim rau redisperse, tsis nplaum, thiab zoo flocculated hais. Tus nqi li ib txwm yog 0.5% rau 1.5%.
4.4 tau siv los ua qhov thaiv, qeeb thiab tswj tso tawm cov neeg sawv cev thiab tus neeg saib xyuas tus neeg sawv cev
Cov qib siab-viscosity ntawm cov khoom lag luam no yog siv los npaj hydrots gel Matrix Ret cov tshuaj tiv thaiv rau cov khoom siv sib xyaw ua ke rau kev sib xyaw ua ke-tso cov ntsiav tshuaj. Nws muaj cov nyhuv ntawm kev ncua kev tso tawm tshuaj. Nws siv kev xav yog 10% ~ 80% (W / W). Qib qis yog siv los ua tus neeg sawv cev ua yeeb yam rau kev txhawb nqa lossis tswj cov yeeb yam. Qhov pib koob tshuaj yuav tsum tau rau txoj kev kho mob ntawm cov ntsiav tshuaj tuaj yeem ncav cuag tau sai, thiab tom qab ntawd cov nyhuv tso tawm tau tawm, thiab cov tshuaj tua hluav taws tau zoo yog tswj hwm hauv lub cev. Hypromellose hydrates los ua cov txheej gel thaum nws sib ntsib nrog dej. Lub tshuab ntawm cov tshuaj tso tawm los ntawm Matrix ntsiav tshuaj yog feem ntau yog qhov diffusion ntawm gel txheej thiab erosion ntawm cov gel txheej.
4.5 Cov kua nplaum tiv thaiv siv ua cov thickener thiab colloid
Thaum cov khoom lag luam no tau siv los ua cov tuab dua, cov kev sib cav ib txwm yog 0.45% ~ 1.0%. Cov khoom no tseem tuaj yeem nce kev ruaj khov ntawm hydrophobic kua nplaum, tiv thaiv cov pa hluav taws xob, tiv thaiv kev ua kom zoo nkauj, ua rau muaj kev tsim ntawm cov peev txheej. Nws li ib txwm muaj siab yog 0.5% ~ 1.5%.
4.6 siv los ua cov tshuaj ntsiav tshuaj
Feem ntau, cov ntsiav tshuaj plhaub cov khoom ntawm cov tshuaj ntsiav yog mas gelatin. Cov txheej txheem ntau lawm ntawm ming capsule Plhaub yog yooj yim, tab sis muaj qee qhov teeb meem thiab oxygen rhiab ntawm cov tshuaj ntsiav ntawm cov ntsiav tshuaj thaum lub sijhawm cia. Yog li ntawd, hypromellose yog siv los hloov pauv rau cov tshuaj ntsiav tshuaj rau cov tshuaj ntsiav, uas txhim kho cov tshuaj ntsiav, thiab tau tshaj tawm hauv tsev thiab txawv teb chaws.
4.7 li biollhesive
Biollhesive thev naus laus zis, daim ntawv thov ntawm expipients nrog rau kev sib txuas thiab cov tshuaj lom neeg maj mam muab tso tawm thiab nqus tau los ntawm mucosa kom ua tiav lub hom phiaj ntawm kev kho mob. Nws yog siv dav tam sim no nws yog siv los kho cov kab mob ntawm lub qhov ntswg kab noj hniav thiab qhov ncauj mucosa. Cov thev naus laus zis tshuab hluav taws xob yog hom kev xa tshuaj tshiab tsim nyob rau xyoo tas los no. Nws tsis yog tsuas yog ncua sij hawm lub sij hawm npaj tshuaj nyob rau hauv lub plab zom mov, tab sis kuj tseem txhim kho cov tshuaj sib haum thiab hloov cov kua ntawm lub cell membrane. Lub zog ntawm cov tshuaj rau cov tshuaj epithelial ntawm cov hnyuv yog txhim kho, yog li kev txhim kho cov xyoob ntawm cov tshuaj.
4.8 raws li cov kua pleev
Raws li kev npaj ua kom zoo nkauj rau daim tawv nqaij, Gel muaj cov txiaj ntsig zoo xws li kev nyab xeeb, kev tu cev, cov txheej txheem npaj yooj yim, thiab kev sib raug zoo, thiab kev sib raug zoo, thiab kev sib raug zoo, thiab kev sib raug zoo, thiab kev sib raug zoo, thiab kev sib raug zoo, thiab kev sib raug zoo, thiab kev sib raug zoo, thiab kev sib raug zoo, thiab kev sib raug zoo, thiab kev sib raug zoo nrog tshuaj. Nyob rau hauv xyoo tsis ntev los no, nws tau txais ntau ntau thiab tau dhau los ua kev txhim kho ntawm daim tawv nqaij npaj. kev taw qhia.
4.9 raws li ib qho nag lossis daus inhibitor nyob rau hauv lub emulsification system
Lub Sijhawm Post: Dec-16-2021