Hydroxypropylmethylcellulose (HPMC) yog ntau yam polymer uas tau siv dav hauv ntau lub lag luam vim nws cov khoom tshwj xeeb. Cov tshuaj no yog ib qho derivative ntawm cellulose, ib tug natural polymer pom nyob rau hauv cov nroj tsuag cell phab ntsa. Lub synthesis ntawm HPMC suav nrog kev kho cellulose nrog propylene oxide los qhia cov pab pawg hydroxypropyl thiab nrog methyl chloride los qhia methyl pawg. Cov txiaj ntsig polymer nthuav tawm ntau yam ntawm lub cev thiab tshuaj lom neeg, ua rau nws tsim nyog rau kev siv tshuaj, kev tsim kho, zaub mov thiab lwm yam lag luam.
1.Chemical qauv thiab muaj pes tsawg leeg:
Hydroxypropyl methylcellulose yog semi-synthetic polymer nrog cov qauv tshuaj complex. Cov pob txha pob txha polymer muaj cov cellulose, cov kab sib txuas ntawm cov piam thaj molecules txuas los ntawm β-1,4-glycosidic bonds. Cov pab pawg hydroxypropyl yog qhia los ntawm kev hloov cov pab pawg hydroxyl (-OH) nrog ib pab pawg propyl, thiab pawg methyl tau qhia zoo ib yam. Qhov degree ntawm kev hloov pauv (DS) sawv cev rau qhov nruab nrab ntawm cov hydroxypropyl thiab methyl pawg ntawm cov piam thaj hauv ib chav tsev thiab cuam tshuam rau solubility, viscosity, thiab thermal zog ntawm cov polymer.
2. Solubility:
Ib qho ntawm cov yam ntxwv tshwj xeeb ntawm HPMC yog nws tus cwj pwm sib cais. Nws yog soluble nyob rau hauv ob qho tib si dej txias thiab kub, muab tshwj xeeb zoo nyob rau hauv ntau yam kev siv. Solubility tuaj yeem hloov kho los ntawm kev kho cov qib ntawm kev hloov pauv thiab qhov hnyav molecular ntawm cov polymer. Cov cuab yeej no ua rau HPMC yog tus neeg sib tw zoo tshaj plaws rau kev tswj hwm-tso tshuaj xa cov tshuab, qhov twg qhov kev sib cais ua lub luag haujlwm tseem ceeb hauv kev tso tshuaj kinetics.
3. Viscosity:
Hydroxypropyl methylcellulose muaj nyob rau hauv ntau yam viscosity qib, nyob ntawm seb yam xws li qhov hnyav molecular, qib ntawm kev hloov pauv, thiab kev daws teeb meem. Lub viscosity ntawm HPMC cov kev daws teeb meem tso cai rau lawv siv rau hauv ntau daim ntawv thov kev lag luam, suav nrog cov tshuaj, ua cov thickeners hauv cov ntaub ntawv ua kua, thiab ua cov ntaub ntawv ua yeeb yaj kiab rau txheej txheej.
4. Film-forming kev ua tau zoo:
Lub peev xwm ua yeeb yaj kiab ntawm HPMC yog qhov tseem ceeb hauv cov ntawv thov xws li tshuaj pleev xim, qhov twg nws yog siv los muab cov txheej txheem tiv thaiv los npog cov saj ntawm cov tshuaj, tswj cov tshuaj tso tawm, thiab txhim kho kev ruaj ntseg. HPMC cov yeeb yaj kiab yog qhov tseeb thiab hloov tau, thiab lawv cov khoom tuaj yeem hloov kho los ntawm kev kho cov polymer concentration, molecular hnyav thiab cov ntsiab lus yas.
5. Thermal kev ua haujlwm:
Hydroxypropyl methylcellulose pom zoo thermal stability nyob rau hauv ib tug tshwj xeeb kub kub. Cov khoom cua sov yog cuam tshuam los ntawm cov yam ntxwv xws li kev hloov pauv, qhov hnyav molecular, thiab muaj cov plasticizers. Cov khoom no ua rau HPMC tsim nyog rau cov ntawv thov uas thermal stability yog qhov tseem ceeb, xws li kev npaj cov tshuaj ua kom sov-rhiab heev.
6. Biocompatibility:
Hauv kev lag luam tshuaj thiab biomedical, biocompatibility yog qhov tseem ceeb rau kev txiav txim siab rau cov khoom siv hauv kev xa tshuaj. Hydroxypropyl methylcellulose feem ntau suav hais tias muaj kev nyab xeeb thiab muaj biocompatibility zoo. Nws yog dav siv nyob rau hauv lub formulation ntawm qhov ncauj ntau npaum cov ntaub ntawv, ophthalmic daws thiab tswj-tso tshuaj xa systems.
7. Dej tuav thiab thickening zog:
HPMC lub peev xwm khaws cov dej thiab cov kua nplaum tuab ua rau nws muaj txiaj ntsig zoo hauv cov khoom siv xws li cov khoom siv cement. Hauv cov ntawv thov no, HPMC ua tus neeg saib xyuas dej, txhim kho kev ua haujlwm thiab tiv thaiv kom qhuav ntxov ntawm cov khoom. Thickening zog kuj tau siv ntau yam khoom noj khoom haus los txhim kho kev ntxhib los mos thiab qhov ncauj.
8. Tswj-tso tshuaj xa tuaj:
Ib qho ntawm cov kev siv tseem ceeb ntawm hydroxypropyl methylcellulose yog nyob rau hauv kev tsim ntawm kev tswj-tso tshuaj xa cov tshuab. Lub polymer lub solubility, viscosity, thiab film-forming zog pab tswj kev tso tawm ntawm cov tshuaj, ua kom muaj kev ruaj ntseg thiab lub hom phiaj xa tshuaj. Qhov no tshwj xeeb tshaj yog muaj txiaj ntsig zoo rau kev txhim kho cov neeg mob ua raws cai thiab txo cov kev mob tshwm sim cuam tshuam nrog kev tso tshuaj sai.
9. Kev ruaj ntseg nyob rau hauv qhov sib txawv pH ib puag ncig:
HPMC nthuav tawm kev ruaj ntseg tshaj pH ntau yam, ua rau nws tsim nyog rau cov formulations uas yuav tsum tau stability nyob rau hauv acidic los yog alkaline tej yam kev mob. Cov cuab yeej no muaj txiaj ntsig zoo hauv cov tshuaj vim tias cov tshuaj formulations yuav ntsib cov pH sib txawv nyob rau hauv lub plab zom mov.
10. Rheological zog:
Tus cwj pwm rheological ntawm HPMC cov kev daws teeb meem yog qhov tseem ceeb rau cov ntawv thov uas cov khoom ntws tseem ceeb, xws li hauv kev npaj cov txheej, cov nplaum thiab cov gels. Cov khoom rheological tuaj yeem raug kho los ntawm kev kho cov concentration thiab molecular hnyav ntawm HPMC kom ua tiav cov yam ntxwv ntws uas xav tau rau kev tswj hwm e-tswj.
Hydroxypropyl methylcellulose tau dhau los ua ib qho tseem ceeb ntawm cov polymer hauv ntau qhov kev lag luam vim nws qhov tshwj xeeb ua ke ntawm solubility, viscosity, film-forming peev xwm thiab biocompatibility. Nws versatility ua rau nws haum rau ntau yam kev siv, los ntawm cov kws kho mob thiab cov ntaub ntawv siv rau cov khoom noj thiab tshuaj pleev ib ce. Raws li cov kws tshawb fawb txuas ntxiv tshawb nrhiav cov qauv tshiab thiab cov ntawv thov, cov khoom ntawm hydroxypropyl methylcellulose yuav ua rau muaj kev vam meej hauv ntau qhov chaw, kom ntseeg tau tias nws tseem ceeb hauv cov ntaub ntawv tshawb fawb thiab kev lag luam.
Post lub sij hawm: Jan-10-2024