Hydroxypropyl methylcellulose (HPMC) yog ntau yam polymer uas tau siv dav hauv kev lag luam tshuaj, tshwj xeeb hauv cov tshuaj ntsiav tshuaj. Raws li cov cellulose derivative, HPMC muaj ntau yam kev ua haujlwm uas pab txhawb rau kev ua haujlwm ntawm cov ntsiav tshuaj tag nrho. Lub compound yog muab los ntawm cellulose los ntawm kev hloov kho tshuaj lom neeg, ua rau cov khoom muaj cov khoom tshwj xeeb haum rau ntau yam kev siv. Hauv cov ntsiav tshuaj formulations, HPMC muaj ntau yam kev siv, nrog rau kev tswj cov tshuaj tso tawm, txhim kho cov ntsiav tshuaj cohesion, thiab txhim kho tag nrho kev ruaj ntseg ntawm daim ntawv ntau npaum.
1. Binders thiab granulating agents:
HPMC ua raws li kev sib khi hauv cov ntsiav tshuaj formulations, pab khi cov khoom xyaw ua ke thiab tiv thaiv cov ntsiav tshuaj ntxov ntxov. Nws kuj yog siv los ua tus neeg sawv cev granulating thaum lub sijhawm tsim khoom, pab cov tshuaj thiab cov khoom sib xyaw ua ke los tsim cov granules.
2. Matrix tsim cov neeg sawv cev rau kev tswj kev tso tawm:
Ib qho txiaj ntsig tseem ceeb ntawm kev siv HPMC hauv cov tshuaj ntsiav tshuaj yog nws lub peev xwm los tswj cov tshuaj tso tawm. Thaum siv los ua cov matrix qub, HPMC tsim cov gel-zoo li matrix thaum sib cuag nrog dej, tso cai rau kev txhawb nqa thiab tswj cov tshuaj tso tawm. Qhov no yog ib qho tseem ceeb tshwj xeeb rau cov tshuaj uas kho qhov rais nqaim lossis xav tau kev ua haujlwm ntev.
3. Disintegrant:
Ntxiv nrog rau nws lub luag haujlwm ua tus tuav ntaub ntawv, HPMC kuj tseem ua haujlwm tsis sib xws hauv cov tshuaj ntsiav tshuaj. Thaum cov ntsiav tshuaj los rau hauv kev sib cuag nrog cov kua dej hauv plab, HPMC swells thiab cuam tshuam cov qauv ntawm cov ntsiav tshuaj, txhawb kev tso tshuaj sai. Qhov no yog tshwj xeeb tshaj yog pab tau rau tam sim tso formulations.
4. Zaj duab xis txheej:
HPMC feem ntau yog siv rau cov ntsiav tshuaj zaj duab xis txheej. HPMC tsim cov yeeb yaj kiab uas txhim kho cov tsos ntawm cov ntsiav tshuaj, muab kev tiv thaiv kev tiv thaiv ib puag ncig, thiab tseem tuaj yeem siv rau kev saj ntsej muag. Cov txheej txheem txheej zaj duab xis yog siv cov tshuaj HPMC rau saum npoo ntawm cov ntsiav tshuaj thiab tsim cov txheej txheem thiab pob tshab tom qab ziab.
5. Tswj porosity thiab permeability modifiers:
Cov ntsiav tshuaj yuav xav tau cov yam ntxwv tshwj xeeb porosity thiab permeability kom ua tiav qhov kev xav tau ntawm qhov profile. HPMC tuaj yeem siv los hloov cov porosity thiab permeability ntawm cov ntsiav tshuaj, cuam tshuam rau kev tso tshuaj. Qhov no yog qhov tseem ceeb kom ua tiav qhov xav tau pharmacokinetic profile ntawm cov tshuaj.
6. Tablet Lubricant:
HPMC ua raws li cov ntsiav tshuaj lubricant, txo kev sib txhuam ntawm cov ntsiav tshuaj thiab cov khoom siv ua haujlwm thaum lub sijhawm tsim khoom. Qhov no pab txhawb txoj kev tsim cov ntsiav tshuaj kom zoo thiab ua kom cov ntsiav tshuaj tsis lo rau cov khoom siv.
7. Mucoadhesives:
Hauv qee cov qauv, tshwj xeeb tshaj yog rau kev xa cov tshuaj buccal lossis qhov ncauj mucosal, HPMC tuaj yeem siv los ua tus neeg sawv cev mucoadhesive. Nws pab txuas ntxiv lub sijhawm nyob ntawm daim ntawv ntau npaum li cas ntawm qhov chaw mucosal, yog li txhim kho kev nqus tshuaj.
8. Stability enhancer:
HPMC pab txhim kho kev ruaj ntseg ntawm cov ntsiav tshuaj formulations los ntawm kev tiv thaiv kev nqus noo noo thiab tiv thaiv cov tshuaj los ntawm ib puag ncig yam. Qhov no yog qhov tseem ceeb tshwj xeeb tshaj yog rau cov tshuaj uas nkag siab rau cov dej noo los yog nquag degradation.
9. Compatibility nrog rau lwm yam excipients:
HPMC muaj kev sib raug zoo nrog ntau yam excipients uas nquag siv hauv cov ntsiav tshuaj formulations. Qhov kev sib raug zoo no ua kom yooj yim tsim cov ntsiav tshuaj nrog ntau yam tshuaj yeeb tshuaj thiab lwm yam khoom xyaw.
Hydroxypropyl methylcellulose (HPMC) plays lub luag haujlwm tseem ceeb hauv cov ntsiav tshuaj formulations, muab ntau lub zog uas pab txhim kho tag nrho cov kev ua tau zoo thiab kev ua tau zoo ntawm daim ntawv ntau npaum. Kev siv ntau yam los ntawm cov binders thiab granulating cov neeg ua haujlwm rau kev tswj kev tso tawm matrix qub, cov ntaub ntawv txheej zaj duab xis, lubricants thiab stability enhancers. Qhov ntau yam ntawm HPMC ua rau nws muaj txiaj ntsig zoo hauv cov tshuaj tsim tshuaj, thiab nws siv txuas ntxiv qhia txog nws qhov tseem ceeb hauv kev ua tiav cov txiaj ntsig xav tau ntawm cov tshuaj xa mus.
Post lub sij hawm: Dec-25-2023