Kev sib xyaw hydroxypropyl methylcellulose (HPMC) yuav tsum tau ua tib zoo saib xyuas kom ntseeg tau tias muaj kev sib cais thiab dej ntawm cov polymer. HPMC yog cov khoom siv ntau yam siv dav hauv tshuaj, tshuaj pleev ib ce, khoom siv, thiab khoom noj khoom haus vim nws cov yeeb yaj kiab tsim, thickening, thiab stabilizing zog. Thaum sib xyaw kom raug, HPMC tuaj yeem muab qhov xav tau sib xws, kev ntxhib los mos, thiab kev ua tau zoo hauv ntau daim ntawv thov.
Nkag siab txog Hydroxypropyl Methylcellulose (HPMC)
Hydroxypropyl methylcellulose (HPMC) yog ib qho hluavtaws polymer muab los ntawm cellulose. Nws yog soluble nyob rau hauv dej tab sis insoluble nyob rau hauv cov organic solvents, ua rau nws zoo tagnrho rau aqueous daim ntaub ntawv. HPMC cov khoom, xws li viscosity, gelation, thiab film-forming peev xwm, txawv nyob ntawm seb yam xws li molecular hnyav, degree ntawm kev hloov, thiab qhov piv ntawm hydroxypropyl rau methyl pawg.
Factors Influencing Mixing:
Particle Loj: HPMC muaj nyob rau hauv ntau qhov ntau thiab tsawg. Fineer particles disperse ntau yooj yim dua coarse sawv daws yuav.
Kub: Cov kub ntau dua feem ntau ua kom tawg thiab tawg. Txawm li cas los xij, cov cua kub ntau dhau tuaj yeem degrade HPMC.
Shear Rate: Kev sib xyaw ua ke uas muab cov shear txaus yog qhov tseem ceeb rau kev faib HPMC kom sib npaug.
pH thiab Ionic Strength: pH thiab ionic zog cuam tshuam HPMC lub solubility thiab hydration kinetics. Kev hloov kho yuav tsim nyog nyob ntawm daim ntawv thov.
Mixing Method Kev Npaj ntawm Dispersion Medium:
Pib los ntawm kev ntxiv qhov xav tau ntawm cov dej deionized lossis distilled rau hauv lub thawv huv. Tsis txhob siv dej tawv, vim nws yuav cuam tshuam rau HPMC qhov kev ua tau zoo.
Yog tias tsim nyog, kho cov pH ntawm cov tshuaj siv cov kua qaub lossis cov hauv paus kom ua kom zoo dua HPMC solubility.
Ntxiv HPMC:
Maj mam sprinkle HPMC rau hauv qhov nruab nrab dispersion thaum stirring tsis tu ncua kom tiv thaiv clumping.
Tsis tas li ntawd, siv cov khoom sib tov sib xyaw ua ke los yog homogenizer kom nrawm dua thiab sib txawv dua.
Mixing Duration:
Txuas ntxiv mus kom txog thaum HPMC tau tawg tag nrho thiab hydrated. Cov txheej txheem no yuav siv sijhawm li ob peb feeb mus rau ib teev, nyob ntawm qib HPMC thiab kev sib xyaw ua ke.
Kev tswj qhov kub thiab txias:
Khaws qhov sib tov kub nyob rau hauv qhov pom zoo kom tiv thaiv kom tsis txhob degradation thiab xyuas kom muaj dej kom zoo.
Tom qab sib tov Stabilization:
Tso cai rau HPMC dispersion kom ruaj khov rau lub sijhawm txaus ua ntej siv, vim qee qhov khoom tuaj yeem txhim kho nrog kev laus.
Kev txiav txim siab rau kev siv sib txawv:
Pharmaceuticals:
Xyuas kom tsis tu ncua dispersion kom ua tiav cov koob tshuaj zoo ib yam thiab tso tshuaj yeeb yaj kiab.
Xav txog kev sib raug zoo nrog lwm cov excipients thiab cov khoom xyaw nquag.
Tshuaj pleev ib ce:
Optimize viscosity thiab rheological zog rau yam khoom yam ntxwv xws li kis tau tus mob thiab stability.
Ntxiv lwm cov additives xws li preservatives thiab antioxidants raws li xav tau.
Khoom siv:
Tswj viscosity kom ua tau raws li qhov xav tau ua haujlwm thiab sib xws hauv cov txheej txheem xws li cov nplaum, tshuaj khib, thiab txheej txheej.
Xav txog kev sib raug zoo nrog lwm cov khoom xyaw thiab ib puag ncig.
Khoom noj khoom haus:
Ua raws li cov qauv zaub mov-qib thiab cov cai.
Xyuas kom muaj kev sib cais kom ua tiav qhov xav tau kev ntxhib los mos, qhov ncauj qhov ntswg, thiab kev ruaj ntseg hauv cov khoom xws li cov kua ntses, hnav khaub ncaws, thiab cov khoom ci.
Kev daws teeb meem:
Clumping lossis agglomeration: Nce tus nqi shear lossis siv cov neeg kho tshuab agitation kom tawg pawg.
Dispersion tsis txaus: Txuas ntxiv sijhawm sib xyaw lossis kho qhov kub thiab pH raws li xav tau.
Viscosity Deviation: Txheeb xyuas HPMC qib thiab concentration; kho formulation yog tsim nyog.
Gelling los yog Flocculation: Tswj kub thiab sib tov ceev kom tsis txhob ntxov ntxov gelation los yog flocculation.
Kev sib xyaw hydroxypropyl methylcellulose (HPMC) yuav tsum tau ua tib zoo xav txog ntau yam xws li particle loj, kub, shear npaum li cas, thiab pH. Los ntawm kev nkag siab txog cov xwm txheej no thiab siv txoj kev sib xyaw kom tsim nyog, koj tuaj yeem ua tiav qhov sib txawv thiab dej ntawm HPMC rau kev ua haujlwm zoo hauv cov tshuaj, tshuaj pleev ib ce, khoom siv, thiab khoom noj khoom haus. Kev saib xyuas thiab kev daws teeb meem tsis tu ncua ua kom cov khoom zoo sib xws thiab kev ua haujlwm zoo.
Post lub sij hawm: Mar-13-2024