HPMC (hydroxypropyl methylcellulose) yog cov thickener thiab stabilizer feem ntau siv hauv cov khoom siv hauv tsev, txheej, tshuaj thiab khoom noj. HPMC 15 cps txhais tau hais tias nws cov viscosity yog 15 centipoise, uas yog qib qis viscosity.
1. Ua kom HPMC concentration
Txoj kev ncaj ncees tshaj plaws thiab ua tau zoo los ua kom cov viscosity ntawm HPMC yog kom nws cov concentration hauv cov tshuaj. Thaum cov feem loj ntawm HPMC nce, cov viscosity ntawm cov tshuaj kuj yuav nce. Lub hauv paus tseem ceeb ntawm txoj kev no yog tias HPMC nce qhov viscosity ntawm cov tshuaj los ntawm kev tsim cov qauv peb-dimensional network. Raws li tus naj npawb ntawm HPMC molecules nyob rau hauv cov kev daws teeb meem nce, qhov ceev thiab lub zog ntawm lub network qauv kuj yuav nce, yog li ua kom cov viscosity ntawm cov tshuaj. Txawm li cas los xij, muaj qhov txwv kom nce qhov concentration. High concentration ntawm HPMC yuav ua rau lub fluidity ntawm cov tshuaj txo, thiab tej zaum yuav cuam tshuam nws cov kev ua tau zoo nyob rau hauv tej kev siv, xws li kev tsim kho thiab kev ua hauj lwm.
2. Tswj qhov kub ntawm cov tshuaj
Qhov kub thiab txias muaj qhov cuam tshuam zoo rau kev solubility thiab viscosity ntawm HPMC. Ntawm qhov kub thiab txias, qhov viscosity ntawm HPMC tov yog siab dua; Thaum nyob rau ntawm qhov kub thiab txias, qhov viscosity ntawm HPMC cov tshuaj yuav txo. Yog li ntawd, txo qhov kub ntawm cov tshuaj kom tsim nyog thaum siv yuav ua rau kom cov viscosity ntawm HPMC. Nws yuav tsum tau muab sau tseg tias cov solubility ntawm HPMC nyob rau hauv cov tshuaj yog txawv ntawm qhov sib txawv kub. Nws yog feem ntau yooj yim rau disperse nyob rau hauv dej txias, tab sis nws yuav siv sij hawm ib tug npaum li cas ntawm lub sij hawm kom yaj tag. Nws yaj sai dua hauv dej sov, tab sis qhov viscosity qis dua.
3. Hloov tus nqi pH ntawm cov kuab tshuaj
Lub viscosity ntawm HPMC kuj rhiab heev rau pH tus nqi ntawm cov tshuaj. Nyob rau hauv nruab nrab los yog ze-nruab nrab tej yam kev mob, lub viscosity ntawm cov tshuaj HPMC yog siab tshaj. Yog tias tus nqi pH ntawm cov tshuaj sib txawv ntawm qhov nruab nrab, qhov viscosity yuav txo qis. Yog li ntawd, qhov viscosity ntawm HPMC cov tshuaj tuaj yeem nce ntxiv los ntawm kev kho tus nqi pH ntawm cov tshuaj kom zoo (piv txwv li, los ntawm kev ntxiv ib qho tsis muaj zog lossis acid-base regulator). Txawm li cas los xij, hauv kev ua haujlwm tiag tiag, kev hloov pauv ntawm tus nqi pH yuav tsum ceev faj heev, vim tias kev hloov pauv loj tuaj yeem ua rau HPMC degradation lossis kev ua haujlwm tsis zoo.
4. Xaiv cov kuab tshuaj uas tsim nyog
Lub solubility thiab viscosity ntawm HPMC hauv cov kuab tshuaj sib txawv yog txawv. Txawm hais tias HPMC feem ntau yog siv hauv cov tshuaj aqueous, qhov sib ntxiv ntawm qee cov kuab tshuaj organic (xws li ethanol, isopropanol, thiab lwm yam) los yog cov ntsev sib txawv tuaj yeem hloov cov saw hlau sib txawv ntawm HPMC molecule, yog li cuam tshuam rau viscosity. Piv txwv li, ib qho me me ntawm cov kuab tshuaj organic tuaj yeem txo qhov cuam tshuam ntawm cov dej molecules ntawm HPMC, yog li ua kom cov viscosity ntawm cov tshuaj. Hauv kev ua haujlwm tshwj xeeb, nws yog qhov yuav tsum tau xaiv cov kuab tshuaj organic tsim nyog raws li daim ntawv thov tiag tiag.
5. Siv cov khoom ua kom tuab
Qee qhov xwm txheej, lwm cov kev pabcuam thickening tuaj yeem muab ntxiv rau HPMC kom ua tiav cov txiaj ntsig ntawm kev nce viscosity. Feem ntau siv cov khoom siv thickening xws li xanthan cov pos hniav, guar cov pos hniav, carbomer, thiab lwm yam. Cov additives no cuam tshuam nrog HPMC molecules los tsim ib lub zog gel los yog network qauv, ntxiv viscosity ntawm cov tshuaj. Piv txwv li, xanthan cov pos hniav yog lub ntuj polysaccharide nrog cov nyhuv thickening. Thaum siv nrog HPMC, ob qho tib si tuaj yeem tsim muaj kev sib koom ua ke thiab ua kom cov viscosity ntawm lub cev muaj zog.
6. Hloov cov qib hloov ntawm HPMC
Lub viscosity ntawm HPMC kuj muaj feem xyuam rau qib ntawm kev hloov ntawm nws cov methoxy thiab hydroxypropoxy pawg. Qib ntawm kev hloov pauv cuam tshuam rau nws cov solubility thiab viscosity ntawm cov tshuaj. Los ntawm kev xaiv HPMC nrog ntau qib kev hloov pauv, qhov viscosity ntawm cov tshuaj tuaj yeem hloov kho. Yog tias yuav tsum muaj cov viscosity ntau dua HPMC, cov khoom lag luam uas muaj cov ntsiab lus methoxy ntau dua tuaj yeem raug xaiv, vim tias qhov siab dua cov ntsiab lus methoxy, qhov muaj zog ntawm HPMC hydrophobicity, thiab cov viscosity tom qab dissolution kuj siab.
7. Nthuav lub sij hawm tawg
Lub sijhawm uas HPMC yaj yuav cuam tshuam rau nws cov viscosity. Yog tias HPMC tsis yaj tag, qhov viscosity ntawm cov tshuaj yuav tsis ncav cuag lub xeev zoo tagnrho. Yog li ntawd, tsim nyog ncua lub sij hawm dissolution ntawm HPMC nyob rau hauv dej los xyuas kom meej tias HPMC yog kiag li hydrated yuav ua tau zoo viscosity ntawm nws cov tshuaj. Tshwj xeeb tshaj yog thaum dissolving ntawm qhov kub thiab txias, cov txheej txheem HPMC dissolution yuav qeeb, thiab ncua sij hawm yog qhov tseem ceeb.
8. Hloov cov txheej txheem shear
Lub viscosity ntawm HPMC kuj muaj feem xyuam nrog lub zog shear nws raug rau thaum siv. Nyob rau hauv siab shear tej yam kev mob, lub viscosity ntawm cov tshuaj HPMC yuav txo tau ib ntus, tab sis thaum lub shear nres, lub viscosity yuav rov qab. Rau cov txheej txheem uas yuav tsum tau nce viscosity, lub shear quab yuam uas cov tshuaj yuav raug txo, los yog nws yuav ua tau nyob rau hauv tsawg shear tej yam kev mob kom muaj ib tug ntau dua viscosity.
9. Xaiv qhov hnyav molecular
Qhov hnyav molecular ntawm HPMC ncaj qha cuam tshuam rau nws cov viscosity. HPMC nrog qhov hnyav dua molecular tsim cov qauv sib txuas loj dua hauv kev daws teeb meem, ua rau muaj viscosity ntau dua. Yog tias koj xav tau kom nce viscosity ntawm HPMC, koj tuaj yeem xaiv HPMC cov khoom uas muaj qhov hnyav dua molecular. Txawm hais tias HPMC 15 cps yog cov khoom lag luam uas tsis muaj viscosity, qhov viscosity tuaj yeem nce ntxiv los ntawm kev xaiv cov khoom sib txawv ntawm cov khoom sib txawv.
10. Xav txog tej yam ib puag ncig
Ib puag ncig yam xws li av noo thiab siab kuj yuav muaj qee yam cuam tshuam rau viscosity ntawm HPMC cov tshuaj. Hauv qhov chaw muaj av noo siab, HPMC tuaj yeem nqus dej noo los ntawm huab cua, ua rau nws cov viscosity txo. Txhawm rau zam qhov no, cov xwm txheej ib puag ncig ntawm qhov chaw tsim khoom lossis siv qhov chaw tuaj yeem tswj tau kom qhov chaw ib puag ncig kom qhuav thiab ntawm qhov tsim nyog los tswj cov viscosity ntawm HPMC cov tshuaj.
Muaj ntau txoj hauv kev los ua kom cov viscosity ntawm HPMC 15 cps tov, suav nrog kev nce siab, tswj qhov kub thiab txias, kho pH, siv cov khoom siv thickening, xaiv cov qib tsim nyog ntawm kev hloov pauv thiab qhov hnyav molecular, thiab lwm yam. Cov txheej txheem tshwj xeeb yuav raug xaiv nyob ntawm daim ntawv thov tiag tiag. scenario thiab txheej txheem yuav tsum tau. Hauv kev ua haujlwm tiag tiag, nws yog qhov yuav tsum tau ua tib zoo xav txog ntau yam thiab ua kom tsim nyog thiab kho kom zoo dua kom ntseeg tau tias kev ua haujlwm zoo tshaj plaws ntawm HPMC kev daws teeb meem hauv cov ntawv thov tshwj xeeb.
Post lub sij hawm: Oct-16-2024