Hydroxypropylmethylcellulose (HPMC) yog cov dej-soluble polymer dav siv hauv ntau yam lag luam xws li tshuaj, khoom noj, tshuaj pleev ib ce, thiab kev tsim kho. HPMC paub txog nws cov khoom tuav dej zoo heev, ua rau nws muaj qhov zoo tshaj plaws hauv ntau daim ntawv thov. Hauv tsab xov xwm no, peb tshuaj xyuas cov xwm txheej uas cuam tshuam rau kev tuav dej ntawm HPMC thiab yuav ua li cas txhawm rau txhim kho cov xwm txheej no kom ua tau zoo tshaj plaws.
1. Molecular hnyav
Qhov hnyav molecular ntawm HPMC plays lub luag haujlwm tseem ceeb hauv nws cov khoom tuav dej. Qhov siab dua qhov hnyav molecular, lub peev xwm khaws dej ntau dua. Qhov no yog vim qhov hnyav molecular hnyav HPMC muaj viscosity ntau dua, uas ua rau nws tsim cov yeeb yaj kiab thicker rau ntawm qhov chaw ntawm lub substrate, yog li txo cov dej poob. Yog li, rau cov ntawv thov uas khaws dej yog qhov tseem ceeb, qhov hnyav molecular HPMC raug pom zoo.
2. Kev hloov pauv
Qib ntawm kev hloov pauv (DS) yog hais txog tus naj npawb ntawm hydroxypropyl thiab methyl pawg hauv HPMC molecule. Qhov siab dua DS, lub peev xwm khaws dej ntau dua. Qhov no yog vim hais tias cov hydroxypropyl thiab methyl pawg ua rau kom cov solubility ntawm HPMC nyob rau hauv dej thiab txhim khu nws lub peev xwm los tsim ib tug gel zoo li sib xws uas yuav haum raws li dej molecules. Yog li, rau cov ntawv thov uas tuav dej yog qhov tseem ceeb, HPMC nrog kev hloov pauv siab tau pom zoo.
3. Kub thiab av noo
Qhov kub thiab av noo yog qhov tseem ceeb cuam tshuam rau kev tuav dej ntawm HPMC. Kev kub siab thiab cov av qis yuav ua rau cov dej hauv HPMC zaj duab xis evaporate sai, ua rau cov dej tsis zoo. Yog li ntawd, nws raug nquahu kom khaws HPMC rau hauv qhov chaw txias thiab qhuav kom nws cov dej khaws cia.
4. tus nqi pH
Lub pH ntawm lub substrate kuj ua lub luag haujlwm tseem ceeb hauv kev tuav dej ntawm HPMC. HPMC yog qhov zoo tshaj plaws nyob rau hauv nruab nrab rau me ntsis acidic ib puag ncig. Thaum pH ntawm matrix siab, cov solubility ntawm HPMC yuav raug txo kom tsawg thiab cov dej tuav cov nyhuv yuav txo. Yog li ntawd, nws raug nquahu kom kuaj pH ntawm substrate thiab kho nws mus rau qhov tsim nyog rau kev tso dej kom zoo.
5. Kev xav
Qhov concentration ntawm HPMC kuj cuam tshuam rau nws cov dej tuav dej. Feem ntau, qhov siab dua ntawm HPMC, qhov dej tuav tau zoo dua. Txawm li cas los xij, ntawm qhov siab heev, qhov viscosity ntawm HPMC tuaj yeem dhau los ua siab dhau, ua rau nws nyuaj rau kev thov thiab kis tusyees ntawm lub substrate. Yog li ntawd, nws raug nquahu kom kuaj xyuas qhov zoo tshaj plaws ntawm HPMC rau txhua daim ntawv thov tshwj xeeb txhawm rau ua tiav cov dej tuav tau zoo tshaj plaws.
Hauv kev xaus, HPMC tau dhau los ua cov khoom tseem ceeb vim nws cov khoom tuav dej zoo heev thiab ua lub luag haujlwm tseem ceeb hauv ntau yam kev lag luam. Cov yam ntxwv cuam tshuam rau nws cov dej tuav, xws li qhov hnyav molecular, qib ntawm kev hloov pauv, kub thiab av noo, pH thiab concentration, tuaj yeem ua kom zoo tshaj plaws kom ua tau zoo. Los ntawm kev nkag siab txog cov xwm txheej no, peb tuaj yeem xyuas kom meej tias HPMCs ncav cuag lawv lub peev xwm tag nrho, ua rau kev tsim cov khoom lag luam zoo rau lawv cov khoom tuav dej.
Post lub sij hawm: Jul-04-2023