HydroxyPropyyl methylulose (HPMC) yog ib feem siv cellule siv nrog ntau cov ntawv thov, xws li cov tshuaj, khoom siv tsim tsev thiab cov tshuaj pleev ib ce. HPMC yog cov tsis-ionic, intert polymer nrog cov dej solubility, thickenive, nplaum thiab zaj duab xis-ua cov khoom.
Cov qauv thiab cov khoom ntawm HPMC
HPMC yog lub cellulose hloov los ntawm kev rov ua cellulose nrog methyl chloride thiab propylene oxide. Nws cov qauv molecular muaj ob lub methyl thiab hydroxypropyl chaw, xws li tshuaj lom neeg, kev tiv thaiv zoo heev, kev tiv thaiv colloid thiab ua yeeb yaj kiab. HPMC tuaj yeem faib ua ntau qhov kev qhia tshwj xeeb raws li cov neeg hloov pauv sib txawv, thiab txhua qhov kev qhia tshwj xeeb muaj cov dej solubility sib txawv thiab siv hauv dej.
Solubility ntawm HPMC hauv dej
Txhim Kho Tshuab
HPMC sib cuam tshuam nrog cov dej lwg me los ntawm hydrogen bonds los tsim kev daws teeb meem. Nws cov txheej txheem sib cais suav nrog cov lwg roj maj mam nti ntawm HPMC, kom cov cohesion, kom cov cohymer chains diffuse rau hauv dej los ua cov tshuaj tsis zoo. Lub solubility ntawm HPMC yog ze ze rau nws txoj haujlwm molecular, hom hloov chaw thiab qib hloov pauv (DS). Feem ntau, cov qib siab dua ntawm kev hloov chaw ntawm cov hloov chaw, siab dua lub solubility ntawm HPMC hauv dej.
Ntxim Kub Kub rau Solubility
Qhov kub yog ib qho tseem ceeb rau kev cuam tshuam rau kev solubility ntawm HPMC. Lub solubility ntawm HPMC hauv dej qhia cov yam ntxwv sib txawv raws li qhov kub hloov:
Qhov kev sib cuam tshuam kub: HPMC nyuaj rau Daws hauv dej txias (feem ntau qis dua 40 ° C), tab sis nws tuaj yeem yaj dua 60 ° C lossis siab dua. Rau qis-viscosity HPMC, dej kub ntawm ib puag ncig 60 ° C feem ntau yog qhov kev sib cais zoo tshaj kub. Rau high-viscosity HPMC, qhov kev sib cais zoo tshaj plaws yog qhov kub ntau npaum li 80 ° C.
Gelation thaum cua txias: Thaum HPMC kev daws teeb meem yog rhuab rau ib qho kub (feem ntau 60-80 ° c) thaum lub sij hawm txias, ib qho thermal gel yuav tsim. Qhov no thermal gel ua ruaj khov tom qab txias mus rau chav sov thiab tuaj yeem muab cov roj liab nyob hauv dej txias. Qhov tshwm sim no yog qhov tseem ceeb tshaj plaws rau kev npaj ntawm HPMC daws teeb meem rau qee hom phiaj (xws li tshuaj ntsiav kom tso tawm).
Kev sib cais ua tau zoo: Feem ntau, siab dua txias tuaj yeem ua rau cov txheej txheem sib cais ntawm HPMC. Txawm li cas los xij, kev kub dhau dhau kuj tseem yuav ua rau muaj kev tsis txaus ntseeg lossis txo qis hauv kev sib txawv viscosity. Yog li ntawd, hauv kev ua haujlwm tiag tiag, qhov tsim nyog sib xyaw ua kom raug xaiv raws li qhov xav tau kom tsis txhob muaj kev txwv tsis txaus thiab cov khoom hloov pauv.
Cov nyhuv ntawm Phes Rau Solubility
Raws li cov neeg tsis-ionic polymer, lub solubility ntawm HPMC hauv dej tsis cuam tshuam ncaj qha los ntawm tus nqi ntawm kev daws teeb meem. Txawm li cas los xij, kev mob siab heev (xws li muaj zog acidic lossis alkaline ib puag ncig) tej zaum yuav cuam tshuam txog kev sib cais ntawm HPMC:
Acidic tej yam kev mob: nyob rau hauv muaj zog acidic tej yam kev mob (xws li ether bonds ntawm nruab nrab, yog li cuam tshuam rau nws solubility thiab dispersibility. Txawm li cas los xij, nyob rau hauv cov dav dav cov kua qaub tsis muaj zog (Ph 3-6), HPMC tseem yuav tau zoo yaj. Alkaline tej yam kev mob: nyob rau hauv cov kev mob alkaline muaj zog (Ph> 11), HPMC yuav txwv, uas feem ntau yog vim muaj hydroxypropyl saw. Nyob rau hauv cov mob tsis muaj zog (pH 7-9), lub solubility ntawm HPMC feem ntau tsis cuam tshuam ntau.
Kev Txhuam Qauv Ntawm HPMC
Txhawm rau kom yaj HPMC, cov hau kev hauv qab no feem ntau yog siv:
Cov Dej Txias Hlau: Maj mam ntxiv HPMC hmoov rau hauv dej txias thaum stirring rau tusyees disperse nws. Txoj kev no tuaj yeem tiv thaiv HPMC los ntawm ncaj qha agglomerating hauv dej, thiab cov kev daws teeb meem ib txheej colloidal tiv thaiv. Tom qab ntawd, maj mam ua cua sov nws txog 60-80 ° C kom yaj nws. Hom no yog tsim nyog rau kev sib nrauj ntawm feem ntau HPMC.
Cov dej ntws dej kub dispersion: Ntxiv HPMC mus rau dej kub thiab do nws sai kom yaj nws sai sai ntawm qhov kub. Cov qauv no haum rau cov visccosity high-viscosity HPMC, tab sis saib xyuas yuav tsum tau them los tswj qhov kub kom tsis txhob muaj kev mob siab.
Daws cov qauv npaj ua ntej: Ua ntej, HPMC yog yaj nyob rau hauv ib lub cev muaj zog (xws li maj mam ntxiv kom hloov nws mus rau hauv ib qho kev daws teeb meem. Hom no yog qhov tsim nyog rau cov kev thov tshwj xeeb nrog kev ua solubility siab.
Kev Kawm Dhuav Tawm Hauv Cov Ntawv Thov Siv
Hauv kev siv cov tswv yim, txheej txheem sib cais ntawm HPMC yuav tsum tau ua kom zoo raws li kev siv tshwj xeeb. Piv txwv li, hauv cov chaw muag tshuaj, nws yog feem ntau tsim nyog los ua ib qho kev sib txuam thiab ruaj khov kho, thiab pawj nruj me ntsis kom ntseeg tau tias cov tshuaj viscosity thiab kev ua haujlwm ntawm kev daws teeb meem. Hauv cov ntaub ntawv hauv tsev, cov solubility ntawm HPMC cuam tshuam cov khoom ua yeeb yaj kiab thiab compressive muaj zog tshaj plaws, yog li qhov zoo tshaj plaws kev xaiv ua ke nrog cov txheej txheem ib puag ncig.
Lub solubility ntawm HPMC hauv dej cuam tshuam los ntawm ntau yam, tshwj xeeb tshaj yog kub thiab ph. Feem ntau hais lus, HPMC tau sib hais nrawm dua ntawm qhov kub siab dua (60-80 ° c), tab sis yuav ua tsis txaus siab lossis tsawg soluble nyob rau hauv siab tshaj plaws. Yog li ntawd, hauv kev siv cov ntawv thov, nws yog ib qho tsim nyog los xaiv qhov tsim nyog sib nrauj thiab pH ntau yam raws kev siv HPMC kom ntseeg tau tias nws cov solubility zoo thiab ua tau zoo.
Lub Sijhawm Post: Jun-25-2024