Hydroxypropyl Methylcellulose (HPMC) yog ib qho kev siv cellulose derivative uas muaj ntau yam kev siv, xws li tshuaj, khoom noj, khoom siv hauv tsev thiab tshuaj pleev ib ce. HPMC yog non-ionic, semi-synthetic, inert polymer nrog zoo heev solubility, thickening, adhesiveness thiab film-forming zog.
Cov qauv thiab cov khoom ntawm HPMC
HPMC yog ib qho kev hloov kho cellulose uas ua los ntawm reacting cellulose nrog methyl chloride thiab propylene oxide. Nws cov qauv molecular muaj ob qho tib si methyl thiab hydroxypropyl substituents, uas muab HPMC tshwj xeeb lub cev thiab tshuaj muaj zog, xws li zoo heev solubility, colloid tiv thaiv thiab zaj duab xis-tsim zog. HPMC tuaj yeem muab faib ua ntau yam tshwj xeeb raws li cov khoom sib txawv, thiab txhua qhov tshwj xeeb muaj qhov sib txawv thiab siv hauv dej.
Solubility ntawm HPMC hauv dej
Dissolution mechanism
HPMC cuam tshuam nrog dej molecules los ntawm hydrogen bonds los tsim ib qho kev daws teeb meem. Nws cov txheej txheem dissolution suav nrog cov dej molecules maj mam nkag mus rau ntawm cov saw molecular ntawm HPMC, rhuav tshem nws txoj kev sib koom ua ke, kom cov saw hlau polymer diffuse mus rau hauv dej los tsim ib qho kev daws teeb meem. Lub solubility ntawm HPMC yog ze ze rau nws qhov hnyav molecular, hloov hom thiab qib kev hloov pauv (DS). Feem ntau, qhov siab dua qhov kev hloov pauv ntawm qhov hloov pauv, qhov siab dua qhov solubility ntawm HPMC hauv dej.
Cov nyhuv ntawm kub rau solubility
Qhov kub thiab txias yog ib qho tseem ceeb cuam tshuam rau kev solubility ntawm HPMC. Lub solubility ntawm HPMC nyob rau hauv dej qhia txawv cov yam ntxwv raws li qhov kub thiab txias hloov:
Dissolution kub ntau: HPMC yog ib qho nyuaj rau yaj nyob rau hauv dej txias (feem ntau qis dua 40 ° C), tab sis nws muaj peev xwm yaj sai dua thaum rhuab mus rau 60 ° C los yog siab dua. Rau cov viscosity tsawg HPMC, dej kub ntawm ib ncig ntawm 60 ° C feem ntau yog qhov zoo tagnrho dissolution kub. Rau high-viscosity HPMC, qhov zoo tshaj plaws dissolution kub ntau yam yuav siab li 80 ° C.
gelation thaum lub sij hawm txias: Thaum HPMC tov yog rhuab mus rau ib tug tej yam kub thiab txias (feem ntau yog 60-80 ° C) thaum lub sij hawm dissolution thiab ces maj mam txias, ib tug thermal gel yuav tsim. Qhov no thermal gel yuav ruaj khov tom qab txias rau hauv chav tsev kub thiab tuaj yeem hloov pauv hauv dej txias. Qhov tshwm sim no tseem ceeb heev rau kev npaj ntawm HPMC cov kev daws teeb meem rau qee lub hom phiaj tshwj xeeb (xws li tshuaj tiv thaiv-tso tshuaj ntsiav).
Dissolution efficiency: Feem ntau, qhov kub siab dua tuaj yeem ua kom cov txheej txheem tawg ntawm HPMC. Txawm li cas los xij, qhov kub thiab txias dhau kuj tuaj yeem ua rau polymer degradation los yog txo qhov kev sib cais viscosity. Yog li ntawd, hauv kev ua haujlwm tiag tiag, qhov tsim nyog qhov ntsuas kub yuav tsum raug xaiv raws li qhov xav tau kom tsis txhob muaj qhov tsis tsim nyog degradation thiab cov khoom hloov pauv.
Cov nyhuv ntawm pH ntawm solubility
Raws li non-ionic polymer, solubility ntawm HPMC hauv dej tsis ncaj qha cuam tshuam los ntawm pH tus nqi ntawm cov tshuaj. Txawm li cas los xij, huab cua pH (xws li muaj zog acidic lossis alkaline ib puag ncig) tuaj yeem cuam tshuam cov yam ntxwv ntawm HPMC:
acidic tej yam kev mob: Nyob rau hauv muaj zog acidic tej yam kev mob (pH <3), ib co tshuaj bonds ntawm HPMC (xws li ether bonds) tej zaum yuav raug puas los ntawm acidic nruab nrab, yog li cuam tshuam nws solubility thiab dispersibility. Txawm li cas los xij, nyob rau hauv qhov tsis muaj zog acid ntau (pH 3-6), HPMC tseem tuaj yeem yaj tau zoo. Alkaline tej yam kev mob: Nyob rau hauv muaj zog alkaline tej yam kev mob (pH> 11), HPMC tej zaum yuav degrade, uas feem ntau yog vim hydrolysis cov tshuaj tiv thaiv ntawm hydroxypropyl saw. Raws li tsis muaj zog alkaline tej yam kev mob (pH 7-9), solubility ntawm HPMC feem ntau tsis cuam tshuam loj heev.
Txoj kev Dissolution ntawm HPMC
Txhawm rau kom ua tiav HPMC zoo, cov hauv qab no feem ntau yog siv:
Txoj kev sib cais dej txias: Maj mam ntxiv HPMC hmoov rau hauv dej txias thaum nplawm kom sib npaug sib npaug. Txoj kev no tuaj yeem tiv thaiv HPMC los ntawm kev sib txuas ncaj qha rau hauv dej, thiab cov kev daws teeb meem tsim cov txheej txheem tiv thaiv colloidal. Tom qab ntawd, maj mam sov nws mus rau 60-80 ° C kom tag nrho yaj nws. Txoj kev no tsim nyog rau kev sib cais ntawm HPMC feem ntau.
Cov dej kub dispersion txoj kev: Ntxiv HPMC rau dej kub thiab do sai sai kom yaj nws sai sai ntawm qhov kub thiab txias. Txoj kev no yog tsim rau high-viscosity HPMC, tab sis yuav tsum tau them nyiaj mloog mus rau kev tswj kub kom tsis txhob degradation.
Txoj kev npaj ua ntej: Ua ntej, HPMC yog yaj hauv cov kuab tshuaj organic (xws li ethanol), thiab tom qab ntawd dej maj mam ntxiv kom hloov mus rau hauv cov kua dej aqueous. Txoj kev no yog tsim rau cov xwm txheej tshwj xeeb nrog rau cov kev xav tau solubility siab.
Kev tshem tawm kev ua haujlwm hauv kev siv tswv yim
Hauv kev siv tswv yim, cov txheej txheem kev sib cais ntawm HPMC yuav tsum tau ua kom zoo raws li kev siv tshwj xeeb. Piv txwv li, nyob rau hauv kev lag luam teb, nws yog feem ntau tsim nyog los tsim ib tug heev uniform thiab ruaj khov colloidal tov, thiab nruj tswj ntawm kub thiab pH yog yuav tsum tau los xyuas kom meej lub viscosity thiab lom ntawm cov tshuaj. Hauv cov khoom siv hauv tsev, kev solubility ntawm HPMC cuam tshuam rau kev tsim cov yeeb yaj kiab thiab lub zog compressive, yog li txoj kev sib cais zoo tshaj plaws yuav tsum tau xaiv ua ke nrog cov xwm txheej tshwj xeeb.
Kev solubility ntawm HPMC hauv dej yog cuam tshuam los ntawm ntau yam, tshwj xeeb tshaj yog kub thiab pH. Feem ntau hais lus, HPMC yaj sai dua ntawm qhov kub siab dua (60-80 ° C), tab sis tej zaum yuav degrade los yog ua kom tsawg dua nyob rau hauv huab cua pH. Yog li ntawd, nyob rau hauv kev siv tswv yim, nws yog tsim nyog los xaiv qhov tsim nyog dissolution kub thiab pH ntau raws li kev siv thiab ib puag ncig tej yam kev mob ntawm HPMC los xyuas kom meej nws zoo solubility thiab kev ua tau zoo.
Post lub sij hawm: Jun-25-2024