Hydroxylopyolin (HPMC) yog ib qho siv dav hauv polymer hauv kev lag luam kws tshuaj thiab yog ib qho tseem ceeb ntawm cov mis. Nws yog tsuas yog siv los ua ib qho nplaum rau hauv cov khoom noj (xws li cov ntsiav tshuaj, tshuaj ntsiav, thiab cov khoom), viscosity enhanced agent thiab decomposition.
Hauv kev npaj tshuaj, kev sib cais ntawm cov khoom xyaw nquag yog qhov tseem ceeb rau kev nqus thiab tsim cov nyhuv kho. Txawm li cas los xij, kev sib cais ntawm cov khoom xyaw nquag tuaj yeem cuam tshuam los ntawm cov qauv. Yog li ntawd, nws yog ib qho tseem ceeb kom nkag siab txog qhov kev coj cwj pwm ntawm HPMC hauv cov tshuaj formula vim tias nws cuam tshuam rau kev ua haujlwm ntawm hom tshuaj.
HPMC txoj kev sib cais
US Pharmacy (USP) tau tsim ib txoj hauv kev rau kev rhuav tshem HPMC. Txoj kev no feem ntau yog siv cov khoom siv dissolving, uas simulates thiab ntsuas qhov solubility ntawm cov tshuaj ntau npaum li cas hauv nruab nrab ntawm cov tshuaj nruab nrab. Qhov kev ntsuam xyuas yuav muab tso rau hauv ib lub pob tawb los yog paddle, thiab lub pob tawb los yog paddle rotates nyob rau hauv ib lub thawv uas muaj qhov nruab nrab yaj.
Qhov nruab nrab solubility yuav tsum raug xaiv raws li qhov xav tau ntawm kev siv ntau npaum li cas (xws li plab hnyuv lossis plab hnyuv). Cov nruab nrab solubility feem ntau rau HPMC suav nrog dej, phosphate buffer tov thiab simulation gastric kua txiv (SGF) los yog analog plab hnyuv kua (SIF).
Txhawm rau kom ntseeg tau qhov rov ua dua thiab raug, cov ntsuas ntsuas yuav tsum yog tus qauv, xws li kev sib hloov ceev, qhov kub thiab txias, thiab qhov ntim nruab nrab thiab lub sijhawm ua piv txwv. Tom qab ntawd siv txoj kev ntsuas tsim nyog los txheeb xyuas cov qauv kev daws teeb meem uas tau txais los ntawm cov sij hawm sib txawv los txiav txim seb tus nqi ntawm HPMC kev puas tsuaj.
Kev Tiv Thaiv Kev Tiv Thaiv Thaum ua HPMC cov kev ntsuam xyuas kev puas tsuaj
1. Kev xaiv ntawm qhov nruab nrab dissolving txoj cai: Kev xaiv ntawm qhov nruab nrab dissolving yog raws li qhov xav tau ntawm kev siv daim ntawv ntau npaum. Kev xaiv qhov nruab nrab ntawm kev sib cais tsim nyog yog qhov tseem ceeb heev vim tias nws yuav cuam tshuam rau HPMC tus cwj pwm dissolving.
2. Kev txheeb xyuas cov txheej txheem solubility kom raug: Txheeb xyuas cov txheej txheem solubility kom paub meej tias nws tsim nyog thiab nws yog ib qho tseem ceeb kom ua tau raws li cov cai ntawm lub koom haum tswj hwm. Kev txheeb xyuas yuav tsum muaj qhov muaj zog thiab rov ua dua ntawm qhov ntsuas.
3. Standardization ntawm kev xeem tsis: xeem tsis, xws li kev sib hloov ceev, kub, thiab yaj nruab nrab ntim cuam tshuam qhov tshwm sim ntawm dissolving xeem. Yog li ntawd, cov kev ntsuas no yuav tsum tau ua tus qauv kom ntseeg tau tias rov tshwm sim dua thiab raug tsom xam.
4. Qauv: Ua tib zoo sampling yog ib qho tseem ceeb kom tau txais cov qauv neeg sawv cev los ntawm qhov nruab nrab dissolving. Ua tib zoo saib xyuas lub sijhawm thiab cov ntsiab lus piv txwv kom paub meej tias cov qauv raug sau nyob rau hauv ib qho kev sib koom ua ke.
5. Txoj kev tsom xam: Xaiv txoj kev tshuaj ntsuam xyuas yuav tsum raug txheeb xyuas, thiab yuav tsum muaj qhov tsim nyog, xaiv thiab raug.
Nyob rau hauv luv luv, lub dissolving xeem ntawm HPMC yog ib tug tseem ceeb lub cuab tam nyob rau hauv kev loj hlob tshuaj thiab tshuaj formula. Lub chaw soj ntsuam kev tswj xyuas zoo tau ua tsis tu ncua los xyuas kom meej qhov tso tawm ntawm cov khoom xyaw nquag, thiab cov tshuaj muaj kev nyab xeeb thiab siv tau zoo. Qhov yuam kev hauv txoj kev sim tsim nyog yuav ua rau muaj kev nkag siab yuam kev thiab cov lus tsis tseeb ntawm kev ua tau zoo ntawm cov tshuaj. Yog li ntawd, nws yog ib qho tseem ceeb uas yuav tsum tau ua raws li cov qauv thiab kev tiv thaiv kev tiv thaiv thaum lub sij hawm kev sib cais.
Post lub sij hawm: Jun-29-2023