Hauv kev lag luam kws tshuaj, sodium carboxymethylcellulose (CMC) thiab hydroxypropyl methylcellulose (HPMC) yog ob qho khoom siv tshuaj uas muaj ntau yam tshuaj lom neeg thiab ua haujlwm.
Cov qauv tshuaj thiab cov khoom
CMC yog cov dej-soluble cellulose derivative tau los ntawm kev hloov ib feem ntawm hydroxyl pawg ntawm cellulose rau hauv pawg carboxymethyl.Cov dej solubility thiab viscosity ntawm CMC nyob ntawm nws qib ntawm kev hloov pauv thiab qhov hnyav molecular, thiab nws feem ntau coj los ua ib qho zoo thickener thiab suspending agent.
HPMC tau los ntawm kev hloov ib feem ntawm pawg hydroxyl ntawm cellulose nrog methyl thiab hydroxypropyl pawg.Piv nrog CMC, HPMC muaj qhov dav dua solubility, tuaj yeem yaj hauv dej txias thiab kub, thiab nthuav tawm cov viscosity ruaj khov ntawm cov pH sib txawv.HPMC feem ntau yog siv los ua zaj duab xis qub, nplaum, thickener thiab tswj kev tso tawm tus neeg sawv cev hauv cov tshuaj.
Daim ntawv thov teb
Cov ntsiav tshuaj
Hauv kev tsim cov ntsiav tshuaj, CMC feem ntau yog siv los ua disintegrant thiab nplaum.Raws li ib tug disintegrant, CMC tuaj yeem nqus dej thiab o, yog li txhawb kev tawg ntawm cov ntsiav tshuaj thiab ua kom cov tshuaj tso tawm.Raws li ib tug binder, CMC tuaj yeem txhim kho lub zog ntawm cov ntsiav tshuaj.
HPMC feem ntau yog siv los ua zaj duab xis qub thiab tswj kev tso tawm hauv cov ntsiav tshuaj.Cov yeeb yaj kiab tsim los ntawm HPMC muaj lub zog zoo heev thiab hnav tsis kam, uas tuaj yeem tiv thaiv cov tshuaj los ntawm kev cuam tshuam ntawm ib puag ncig sab nraud.Tib lub sijhawm, cov yeeb yaj kiab tsim cov khoom ntawm HPMC kuj tuaj yeem siv los tswj qhov tso tawm ntawm cov tshuaj.Los ntawm kev kho hom thiab ntau npaum li cas ntawm HPMC, qhov kev tso tawm ruaj khov lossis tswj kev tso tawm tuaj yeem ua tiav.
Capsules
Hauv kev npaj tshuaj ntsiav, CMC siv tsawg dua, thaum HPMC tau siv dav, tshwj xeeb tshaj yog nyob rau hauv kev tsim cov neeg tsis noj nqaij capsules.Cov tshuaj ntsiav tshuaj feem ntau yog ua los ntawm gelatin, tab sis vim muaj teeb meem ntawm cov tsiaj, HPMC tau dhau los ua cov khoom siv zoo tshaj plaws.Lub plhaub capsule ua los ntawm HPMC tsis tsuas yog muaj biocompatibility zoo, tab sis kuj ua tau raws li cov kev xav tau ntawm cov neeg tsis noj nqaij.
Kev npaj ua kua
Vim nws cov khoom zoo heev thickening thiab ncua kev kawm ntawv, CMC yog dav siv nyob rau hauv kev npaj ua kua xws li tshuaj qhov ncauj, qhov muag tee thiab tshuaj pleev.CMC tuaj yeem ua kom cov viscosity ntawm cov dej npaj, yog li txhim kho qhov kev ncua thiab kev ruaj ntseg ntawm cov tshuaj thiab tiv thaiv cov tshuaj sedimentation.
Daim ntawv thov ntawm HPMC nyob rau hauv cov kua npaj yog mas concentrated nyob rau hauv thickeners thiab emulsifiers.HPMC tuaj yeem nyob ruaj khov ntawm ntau yam pH thiab tuaj yeem sib haum nrog ntau yam tshuaj yam tsis muaj kev cuam tshuam rau kev ua tau zoo ntawm cov tshuaj.Tsis tas li ntawd, cov cuab yeej ua yeeb yaj kiab ntawm HPMC kuj tau siv rau hauv cov tshuaj pleev ib ce, xws li cov yeeb yaj kiab-tsim kev tiv thaiv hauv qhov muag tee.
Tswj kev tso tawm npaj
Hauv kev tswj hwm kev npaj tawm, daim ntawv thov ntawm HPMC yog qhov tshwj xeeb.HPMC muaj peev xwm tsim ib lub gel network, thiab qhov tso tawm ntawm cov tshuaj tuaj yeem tswj tau los ntawm kev kho qhov concentration thiab cov qauv ntawm HPMC.Cov cuab yeej no tau dav siv nyob rau hauv qhov ncauj sustained-tso ntsiav tshuaj thiab implants.Nyob rau hauv sib piv, CMC yog tsawg siv nyob rau hauv kev tswj-tso npaj, feem ntau vim hais tias cov gel qauv nws cov ntaub ntawv tsis ruaj khov li HPMC.
Stability thiab compatibility
CMC muaj kev ruaj ntseg tsis zoo ntawm cov pH sib txawv thiab yooj yim cuam tshuam los ntawm acid-base ib puag ncig.Tsis tas li ntawd, CMC muaj kev sib raug zoo tsis zoo nrog qee cov khoom xyaw tshuaj, uas yuav ua rau cov tshuaj los nag lossis tsis ua haujlwm.
HPMC qhia tau hais tias muaj kev ruaj ntseg zoo tshaj pH ntau yam, tsis yooj yim cuam tshuam los ntawm acid-base, thiab muaj kev sib raug zoo heev.HPMC tuaj yeem sib xyaw nrog cov khoom xyaw tshuaj feem ntau yam tsis muaj kev cuam tshuam rau kev ruaj ntseg thiab kev ua tau zoo ntawm cov tshuaj.
Kev nyab xeeb thiab kev cai
Ob leeg CMC thiab HPMC raug suav hais tias yog cov khoom siv tshuaj muaj kev nyab xeeb thiab tau pom zoo siv rau hauv kev npaj tshuaj los ntawm cov chaw muag tshuaj thiab cov koom haum tswj hwm hauv ntau lub tebchaws.Txawm li cas los xij, thaum siv, CMC tuaj yeem ua rau qee qhov kev tsis haum tshuaj lossis tsis xis nyob hauv plab, thaum HPMC tsis tshua muaj tshwm sim tsis zoo.
CMC thiab HPMC muaj lawv tus kheej zoo hauv kev siv tshuaj.CMC tuav lub luag haujlwm tseem ceeb hauv kev npaj ua kua vim nws cov khoom ua kom tuab thiab ncua kev kawm zoo, thaum HPMC tau siv dav hauv cov ntsiav tshuaj, tshuaj ntsiav thiab tswj-tso npaj vim nws cov yeeb yaj kiab zoo tshaj plaws thiab kev tswj hwm kev tso tawm.Kev xaiv cov tshuaj npaj yuav tsum tau ua raws li cov tshuaj tshwj xeeb thiab cov kev xav tau ntawm kev npaj, ua tib zoo xav txog qhov zoo thiab qhov tsis zoo ntawm ob qho tib si, thiab xaiv cov khoom tsim nyog tshaj plaws.
Post lub sij hawm: Lub Xya hli ntuj-19-2024