Kev siv tshuaj qib hydroxypropyl methylcellulose (HPMC)

Hydroxypropyl methylcellulose (HPMC) yog ib qho hluavtaws semi-synthetic polymer dav siv nyob rau hauv ntau lub lag luam, tshwj xeeb tshaj yog nyob rau hauv cov kws tshuaj. HPMC tau dhau los ua ib qho khoom tseem ceeb hauv kev npaj tshuaj vim nws cov biocompatibility, tsis muaj tshuaj lom thiab zoo heev lub cev thiab tshuaj.

(1) Cov yam ntxwv tseem ceeb ntawm qib tshuaj HPMC
HPMC yog non-ionic cellulose ether npaj los ntawm cov tshuaj tiv thaiv ntawm cellulose nrog propylene oxide thiab methyl chloride nyob rau hauv alkaline tej yam kev mob. Nws cov qauv tshuaj tshwj xeeb muab HPMC zoo heev solubility, thickening, film-forming thiab emulsifying zog. Cov hauv qab no yog qee qhov tseem ceeb ntawm HPMC:

Dej solubility thiab pH dependence: HPMC dissolves nyob rau hauv dej txias thiab tsim ib tug pob tshab viscous tov. Lub viscosity ntawm nws cov tshuaj muaj feem xyuam rau cov concentration thiab molecular hnyav, thiab nws muaj zog stability rau pH thiab yuav nyob ruaj khov nyob rau hauv ob qho tib si acidic thiab alkaline ib puag ncig.

Thermogel khoom: HPMC nthuav tawm cov khoom tshwj xeeb thermogel thaum cua sov. Nws tuaj yeem tsim cov gel thaum rhuab mus rau ib qho kub thiab rov qab mus rau lub xeev ua kua tom qab txias. Cov cuab yeej no tseem ceeb tshwj xeeb hauv kev npaj tshuaj tiv thaiv-tso tawm.
Biocompatibility thiab non-toxicity: Txij li HPMC yog ib qho derivative ntawm cellulose thiab tsis muaj nqi thiab yuav tsis hnov ​​​​mob nrog lwm cov khoom xyaw, nws muaj biocompatibility zoo heev thiab yuav tsis absorbed rau hauv lub cev. Nws yog ib qho uas tsis yog-tshuaj lom excipient.

(2) Kev siv HPMC hauv cov tshuaj
HPMC yog dav siv nyob rau hauv kev lag luam kws tshuaj, npog ntau yam xws li qhov ncauj, tshuaj pleev ib ce thiab txhaj tshuaj. Nws cov lus qhia tseem ceeb ntawm kev thov yog raws li hauv qab no:

1. Cov khoom siv ua yeeb yaj kiab hauv cov ntsiav tshuaj
HPMC yog dav siv nyob rau hauv txheej txheej ntawm cov ntsiav tshuaj raws li ib tug zaj duab xis-tsim cov ntaub ntawv. Cov ntsiav tshuaj txheej tuaj yeem tsis tsuas yog tiv thaiv cov tshuaj los ntawm kev cuam tshuam ntawm ib puag ncig sab nraud, xws li ya raws thiab lub teeb, tab sis kuj npog cov ntxhiab tsw phem thiab saj ntawm cov tshuaj, yog li txhim kho kev ua raws li tus neeg mob. Cov yeeb yaj kiab tsim los ntawm HPMC muaj cov dej tsis zoo thiab lub zog, uas tuaj yeem ua kom ntev lub txee lub neej ntawm cov tshuaj.

Tib lub sijhawm, HPMC tseem tuaj yeem siv los ua cov khoom tseem ceeb ntawm kev tswj-tso daim nyias nyias rau kev tsim cov tshuaj tiv thaiv-tso tawm thiab tswj-tso cov ntsiav tshuaj. Nws cov khoom thermal gel tso cai rau cov tshuaj tso tawm hauv lub cev ntawm tus nqi tso tawm ua ntej, yog li ua tiav cov txiaj ntsig ntawm kev kho tshuaj ntev. Qhov no yog qhov tseem ceeb tshwj xeeb hauv kev kho cov kab mob ntev, xws li kev xav tau tshuaj mus sij hawm ntev ntawm cov neeg mob ntshav qab zib thiab kub siab.

2. Raws li tus neeg saib xyuas kev tso tawm
HPMC tau dav siv los ua tus neeg sawv cev tso tawm hauv kev npaj tshuaj hauv qhov ncauj. Vim tias nws tuaj yeem tsim cov gel hauv dej thiab cov gel txheej maj mam yaj thaum cov tshuaj tso tawm, nws tuaj yeem tswj tau qhov tso tawm ntawm cov tshuaj. Daim ntawv thov no yog ib qho tseem ceeb tshwj xeeb hauv cov tshuaj uas yuav tsum tau tso tshuaj ntev ntev, xws li insulin, tshuaj tiv thaiv kev nyuaj siab, thiab lwm yam.

Nyob rau hauv lub plab zom mov ib puag ncig, cov gel txheej ntawm HPMC tuaj yeem tswj hwm qhov tso tawm ntawm cov tshuaj, zam kev tso tawm sai sai ntawm cov tshuaj hauv lub sijhawm luv luv, yog li txo cov kev mob tshwm sim thiab ua kom ntev. Cov cuab yeej txhawb nqa-tso tawm no tshwj xeeb yog tsim nyog rau kev kho mob ntawm cov tshuaj uas xav tau cov tshuaj ntshav ruaj khov, xws li tshuaj tua kab mob, tshuaj tiv thaiv kab mob vwm, thiab lwm yam.

3. Raws li ib tug binder
HPMC feem ntau yog siv los ua cov ntaub ntawv hauv cov txheej txheem tsim cov ntsiav tshuaj. Los ntawm kev ntxiv HPMC rau cov tshuaj siv tshuaj los yog hmoov, nws cov fluidity thiab adhesion tuaj yeem txhim kho, yog li txhim kho cov nyhuv compression thiab lub zog ntawm cov ntsiav tshuaj. Lub non-toxicity thiab stability ntawm HPMC ua rau nws zoo tagnrho binder nyob rau hauv cov ntsiav tshuaj, granules thiab capsules.

4. Raws li cov thickener thiab stabilizer
Hauv kev npaj ua kua, HPMC yog dav siv los ua cov thickener thiab stabilizer nyob rau hauv ntau yam kua qhov ncauj, qhov muag tee thiab tshuaj pleev ib ce. Nws cov cuab yeej thickening tuaj yeem ua rau kom cov viscosity ntawm cov tshuaj ua kua, tsis txhob siv tshuaj stratification lossis nag lossis daus, thiab xyuas kom cov khoom sib xyaw ntawm cov tshuaj sib xyaw. Nyob rau tib lub sijhawm, lubricity thiab moisturizing zog ntawm HPMC pab kom nws txo qhov muag tsis xis nyob hauv qhov muag tee thiab tiv thaiv ob lub qhov muag los ntawm kev khaus sab nraud.

5. Siv hauv tshuaj ntsiav
Raws li cov nroj tsuag-derived cellulose, HPMC muaj biocompatibility zoo, ua rau nws yog ib qho tseem ceeb rau kev ua cov tshuaj ntsiav. Piv nrog rau cov tsiaj gelatin capsules, HPMC capsules muaj kev ruaj ntseg zoo dua, tshwj xeeb tshaj yog nyob rau hauv qhov kub thiab txias ib puag ncig, thiab tsis yooj yim rau deform los yog yaj. Tsis tas li ntawd, HPMC capsules yog tsim rau cov neeg tsis noj nqaij thiab cov neeg mob uas tsis haum rau gelatin, nthuav dav ntawm kev siv tshuaj ntsiav tshuaj.

(3) Lwm yam kev siv tshuaj ntawm HPMC
Ntxiv nrog rau cov ntawv thov siv tshuaj ntau tshaj saum toj no, HPMC kuj tuaj yeem siv tau hauv qee thaj chaw tshuaj. Piv txwv li, tom qab phais kho qhov muag, HPMC yog siv rau hauv qhov muag tee ua lub roj nplua nyeem kom txo tau kev sib txhuam ntawm qhov muag ntawm lub qhov muag thiab txhawb kev rov zoo. Tsis tas li ntawd, HPMC kuj tseem siv tau rau hauv cov tshuaj pleev thiab cov gels los txhawb kev nqus tshuaj thiab txhim kho kev ua tau zoo ntawm cov tshuaj hauv zos.

Pharmaceutical qib HPMC ua lub luag haujlwm tseem ceeb hauv kev npaj tshuaj vim nws lub cev zoo thiab tshuaj lom neeg. Raws li ib tug multifunctional pharmaceutical excipient, HPMC tsis tau tsuas yog txhim kho cov stability ntawm cov tshuaj thiab tswj kev tso tawm ntawm cov tshuaj, tab sis kuj txhim kho cov kev siv tshuaj thiab ua rau kom cov neeg mob ua raws li txoj cai. Nrog rau kev nce qib ntawm kev siv tshuaj thev naus laus zis tsis tu ncua, daim ntawv thov teb ntawm HPMC yuav nthuav dav dua thiab ua lub luag haujlwm tseem ceeb hauv kev txhim kho tshuaj yav tom ntej.


Post lub sij hawm: Sep-19-2024