Qhov zoo ntawm HPMC (hydroxypropyl methylcellulose) hauv kev lag luam kws tshuaj tau cuam tshuam los ntawm ntau yam, thiab nws cov khoom tshwj xeeb ua rau nws siv dav hauv excipient.
1. Zoo heev thickening thiab gelling zog
HPMC yog cov khoom siv dej-soluble polymer nrog cov thickening zoo heev thiab gelling zog. Hauv kev tsim tshuaj, HPMC tuaj yeem siv los ua cov thickener thiab gelling tus neeg sawv cev los txhim kho cov viscosity thiab ruaj khov ntawm kev npaj. Qhov no yog qhov tseem ceeb tshwj xeeb tshaj yog rau kev npaj ua kua (xws li cov kua hauv qhov ncauj thiab tee), uas tuaj yeem txhim kho cov khoom ntawm cov tshuaj thiab ua kom muaj kev sib haum xeeb thiab ruaj khov.
2. Biocompatibility
HPMC muaj biocompatibility zoo thiab biodegradability thiab yog haum rau siv nyob rau hauv kev lag luam tshuaj, tshwj xeeb tshaj yog rau kev npaj ntawm qhov ncauj npaj thiab txhaj tshuaj. Vim tias nws yog muab los ntawm cov nroj tsuag, HPMC tsis muaj tshuaj lom thiab tsis muaj teeb meem rau tib neeg lub cev, txo qhov kev pheej hmoo ntawm cov tshuaj tsis zoo.
3. Tswj cov khoom tso tawm
HPMC feem ntau yog siv los npaj cov tshuaj tiv thaiv-tso tawm thiab cov tshuaj tiv thaiv-tso tawm. Nws cov khoom hydration tuaj yeem tswj hwm tus nqi tso tawm ntawm cov tshuaj, ua tiav kev tso tawm ntawm cov tshuaj, txo qhov zaus ntawm kev tswj hwm, thiab txhim kho kev ua raws li tus neeg mob. Cov cuab yeej no tseem ceeb tshwj xeeb hauv kev kho mob ntev, xws li kub siab thiab ntshav qab zib.
4. Zoo heev solubility thiab stability
HPMC yog yooj yim soluble hauv dej thiab tuaj yeem nyob ruaj khov nyob rau hauv qhov sib txawv pH. Qhov no tso cai rau nws siv dav hauv ntau hom kev npaj tshuaj. Txawm hais tias nyob rau hauv ib puag ncig acidic lossis alkaline, HPMC tuaj yeem tswj nws qhov kev ua tau zoo thiab ua kom muaj kev ruaj ntseg ntawm cov tshuaj.
5. Txhim kho bioavailability ntawm cov tshuaj
HPMC tuaj yeem txhim kho bioavailability ntawm qee yam tshuaj, tshwj xeeb tshaj yog rau cov tshuaj tsis zoo soluble. Los ntawm kev sib xyaw nrog cov tshuaj, HPMC tuaj yeem txhim kho qhov nqus ntawm cov tshuaj hauv lub cev thiab txhim kho cov nyhuv kho. Qhov no yog qhov tseem ceeb heev rau kev tsim cov tshuaj tshiab, tshwj xeeb tshaj yog cov tshuaj me me thiab cov tshuaj lom neeg.
6. Zoo heev formability
Hauv cov txheej txheem tshuaj, HPMC tuaj yeem siv los ua ib qho kev sib khi hauv kev npaj cov ntsiav tshuaj thiab tshuaj ntsiav los txhim kho cov formability thiab hardness ntawm kev npaj. Nws tuaj yeem txhim kho lub compressibility ntawm cov tshuaj, xyuas kom meej lub uniformity thiab stability ntawm cov ntsiav tshuaj, thiab txo cov fragmentation tus nqi.
7. Kev siv dav dav
HPMC yog sib xws nrog ntau yam tshuaj thiab yog siv dav hauv ntau yam kev npaj xws li ntsiav tshuaj, tshuaj ntsiav, tshuaj hauv qhov ncauj, txhaj tshuaj, thiab lwm yam. Tsis tas li ntawd, HPMC kuj tseem siv tau los npaj cov emulsions, gels thiab foams, thiab lwm yam., ua qauv qhia. nws versatility nyob rau hauv kev lag luam kws tshuaj.
8. Tus nqi qis
Piv nrog rau lwm cov ntaub ntawv polymer, HPMC muaj tus nqi qis dua, thiab nws lub cev thiab tshuaj lom neeg tuaj yeem hloov kho los ntawm kev hloov cov qib ntawm kev hloov ntawm pawg hydroxyl. Yog li ntawd, daim ntawv thov ntawm HPMC hauv kev lag luam kws tshuaj tsis tsuas yog txhim kho kev ua haujlwm ntawm cov khoom, tab sis kuj txo cov nqi tsim khoom.
Kev siv dav ntawm HPMC hauv kev lag luam kws tshuaj yog qhov tshwm sim ntawm nws cov khoom zoo heev. Txawm hais tias hauv kev txhim kho kev ruaj ntseg thiab bioavailability ntawm cov tshuaj los yog hauv kev txhim kho lub cev lub zog ntawm kev npaj, HPMC tau qhia txog qhov zoo. Nrog rau kev txhim kho cov cuab yeej siv tshuaj, daim ntawv thov kev cia siab ntawm HPMC tseem dav dav, thiab nws yuav tsum ua lub luag haujlwm ntau dua hauv kev txhim kho thiab tsim cov tshuaj tshiab.
Post lub sij hawm: Sep-26-2024